我院151例药品不良反应报告分析

目的:了解我院药品不良反应(ADR)发生的特点及一般规律。方法:对我院2012-2013年上报的151例ADR报告,按患者的性别、年龄、给药途径、药品种类、累及器官或系统及临床表现、ADR报告类型、关联性评价等方面进行回顾性分析。结果:151例ADR报告中60岁以上ADR老年人发生率最高,占28.48%;静脉给药途径ADR发生率最高,占85.43%;抗菌药物引起的ADR占35.10%;抗肿瘤药引起的ADR占25.83%;中药注射剂引起的ADR占14.57%;ADR主要累及皮肤及其附件,占32.45%;严重的ADR报告占31.79%。结论:临床应加强ADR的监测和持续改进工作,以减少ADR的发生,保证用药安全。

Analysis of 161 Adverse Drug Reactions Cases in Our Hospital

OBJECTIVE： To probe into the regularity and characteristics of adverse drug reaction （ADR） cases in our hospital. METHODS： A total of 151 ADR cases reported in our hospital from 2012 to 2013 were analyzed statistically in respects of patients＇ gender and age, route of administration, category of drug, organs or systems involved and clinical manifestations, types of ADR re- ports and relevance evaluation. RESULTS： Of 151 ADR cases, patients aged over 60 occupied great proportion （28.48 % ）; intrave- nous administration accounted for 85.43%, which had the highest incidence of ADR; ADR induced by antibiotics accounted for 35.10% ; ADR induced by antineoplastic drug accounted for 25.83% ; ADR induced by TCM injection accounted for 14.57% ; main clinical manifestations were the lesions of skin and appendents, accounted for 32.46% ; serious ADR accounted for 31.79%. CONCLUSIONS： In order to reduce the incidence of the ADR and ensure the safety of drug use, great importance should be at- tached to ADR monitoring and continuous improvement.