抗精神病药物与强迫症状

目的探讨抗精神病药与强迫症状的关系。方法采用自编调查表对659例门诊精神分裂症病人做问卷调查并对病史资料进行统计分析。结果(1)精神分裂症伴强迫症状者122例,占18.5%(122/659),其中63例强迫症状在服用抗精神病药后出现,占9.6%(63/659);(2)非典型抗精神病药诱发强迫症状的比率依次为氯氮平14.2%,利培酮5.1%,奥氮平1.9%,经典抗精神病药诱发强迫症状的比率共计2.8%;(3)氯氮平高剂量者强迫症状的发生率高于低剂量者,约1/3的病人强迫症状出现在服用氯氮平1年以内,半数以上出现在服氯氮平3年以内。结论抗精神病药诱发的强迫症状并不少见,氯氮平是其中的常见药物,强迫症状的发生与用药剂量和时间有关。

A study of relationship between antipsychotics and obsessive-compulsive symptoms

Objective: To study the relationship between antipsychotics and obsessive-compulsive symptoms.Methods: 659 outpatients with schizophrenia and their case records were assessed with investigation list made by self.Results:(1) There are 122 cases(122/659,18.5%) with OCS, 63 of which occur after taking antipsychotics,9.6%(63/659).(2) The ratio of atypical antipsychotics causing OCS is clozapine 14.2%,risperidone 5.1%,olanzapine1.9% respectively.The ratio of typical antipsychotics is 2.8%.(3)The incidence of OCS cases who heavily dosed with clozapine is higher than those lightly dosed.After taking clozapine,approximately OCS of 1/3 cases occurred within one year,and more than a half cases occurred within three years.Conclusion:OCS caused by antipsychotics is not seldom,clozapine is one of the common factors of causing OCS.The incidence of OCS related to dose and time segment of antipsychotics.