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Longitudinal study of cerebral blood flow in Alzheimer's disease using single photon emission tomography |
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| Authors: | Perminder Sachdev Rakesh Gaur Henry Brodaty Alexandra Walker Susan Meares Deborah Koder Walter Haindl |
| Affiliation: | a Neuropsychiatric Institute, The Prince Henry Hospital, P.O. Box 233, Matraville, NSW, Australia b Academic Department of Psychogeriatrics, The Prince Henry Hospital, P.O. Box 233, Matraville, NSW 2036, Australia c Department of Nuclear Medicine, The Prince of Wales Hospital, Sydney, Australia d School of Psychiatry, University of New South Wales, Sydney, Australia |
| Abstract: | Ten patients with probable Alzheimer's disease were assessed at baseline and a mean 2 years later using a battery of neuropsychological tests, CT scans and Tc99m-HMPAO SPECT scans. The subjects had declined significantly in their functional indices. Cerebral perfusion measures declined in the parietal lobes, left hemisphere and whole brain, but the overall decline did not reach statistical significance. The decline in brain perfusion did not correlate significantly with the decline in various indices of neuropsychological function, either globally or for specific brain regions. The index of cerebral perfusion correlated significantly with global indices of neuropsychological function at baseline but not at follow-up. No single perfusion index was a significant predictor of clinical progression of dementia. |
| Keywords: | Alzheimer's disease SPECT Cerebral blood flow Neuropsychological function |
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