抗心磷脂抗体与几种肾脏疾病的关系

目的　探讨抗心磷脂抗体 (ACL)与几种常见肾脏疾病的关系 ,以及ACL的检测在肾脏病中的应用。方法　采用酶联免疫吸附法 (ELISA)对原发性肾病综合征组 (以ACL阳性和阴性分成两组 )、隐匿性肾炎组、尿毒症组及正常对照组进行ACL检测 ,并对ACL在各组中的阳性率进行比较。结果　正常对照组、隐匿性肾炎组和尿毒症组ACL阳性率分别为 3.33%、3.45 %和 0 % ,3组间比较ACL的阳性率无显著性差异 (P >0 .0 5 ) ,肾病综合征组为 31.5 8% ,与前 3组比较明显增高 (P <0 .0 1)。ACL阳性组 2 4h尿蛋白定量、纤维蛋白原定量、血浆粘度较之ACL阴性组明显增高 (P <0 .0 5 ) ,血ATⅢ 活性 ,血浆白蛋白水平则明显较ACL阴性组低。结论　ACL在原发性肾病综合征病人中的阳性率明显高于正常人及隐匿性肾炎和尿毒症病人。ACL阳性病人存在明显的高凝状态和血栓形成倾向

Relationship between anticardiolipin antibody and renal diseases

Objective To assess the relationship between anticardiolipin antibody (ACL) and renal diseases and the application value of determenation of anticardiolipin antibody in renal disease.Methods The serum levels of ACL were measured by ELISA in patients with primary nephrotic syndrome(who were divided into two groups:the positive and the negtive group according to anticardiolipin antibody), latent nephritis, uraemia and normal controls,and the omparson analysis of positive rate of ACL in groups were carried out. Results The positive rate of ACL in normal controls, latent nephritis and uraemia group was 3.33%, 3.45% and 0 respectivly, there was no difference among these groups(P<0.05). The positive rate in group of nephrotic syndrome was 31.58% ,and was significantly higher than that in the other groups (P<0.01). The content of urine protein excretion, serum fibrinogen and serum viscosity in the ACL positive group were significantly higher than that in the negative group(P<0.05). The activity of serum AT Ⅲ and serum albumin contents in ACL positive gruop were much lower than that in the negative group. Conclusion The positive rate of ACL in patients with nephrotic syndrome is significantly higher than that of normal controls and patients with latent nephritis or uraemia. The patients with ACL positive have state of hypercoaggulation and the tendency of thrombosis.