Allergen-containing drug from Malassezia spp. yeast |
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| Authors: | Arzumanyan V G Bykova S A Serdyuk O A Kozlova N N |
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| Affiliation: | (1) Institute of Microbiology, Russian Academy of Sciences, Russia;(2) I. I. Metchnikov Institute of Vaccines and Sera, Russian Academy of Medical Sciences, Moscowe;(3) I. I. Metchnikov Institute of Vaccines and Sera, Russian Academy of Medical Sciences, Moscow |
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| Abstract: | Malassezia spp. yeast habituating the skin of healthy humans can be a source of allergens for patients with atopic dermatitis. We proposed a method for obtaining allergen-containing preparation by trimming outer cell wall proteins with 1% sodium dodecyl sulfate. The resultant preparation contained 36 and 67 kD proteins known as Malassezia allergens. IgE antibodies to these proteins were detected in the sera of young people with atopic dermatitis. |
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| Keywords: | Malassezia Pityrosporum skin allergen atopic dermatitis IgE antibodies |
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