EGFR及NF-κB与鼻咽癌放射敏感性的相关性研究

目的：通过观察EGFR、NF—κB蛋白表达与鼻咽癌放射敏感性的关系，评价两因子在预测鼻咽癌放射敏感性方面的作用，并为以后靶向基因治疗鼻咽癌、提高放疗效果提供理论依据。方法：采用免疫组织化学SP法检测41例鼻咽癌组织中EGFR及NF-κB的表达情况，并通过随访及临床观察，判断每例患者放疗效果，从而将所有患者分为完全缓解组、部分缓解／稳定组和进展组，评定两因子表达水平与放射敏感性的关系。结果：EGFR、NF-κB在鼻咽癌中均有不同程度表达，两者在鼻咽癌组织的不同放射敏感性中表达各具有差异性（P〈0．05）。完全缓解组与部分缓解／稳定组的EGFR、NF-κB表达均低于进展组（P〈0．05），而完全缓解组与部分缓解／稳定组比较差异无统计学意义（P〉0．05）。两因子表达与鼻咽癌放射敏感性呈负相关。结论：EGFR、NF-κB可能成为预测鼻咽癌放射敏感性的2个重要指标，为鼻咽癌患者的靶向基因治疗提供理论依据。

The relationship between the expression of EGFR NF-κB and radiosensitivity in human nasopharyngeal carcinoma

Objective:To detect the expression of EGFR and NF-ΚB and the relationship between the two fac-tors and radiosensitivity in human nasopharyngeal carcinoma. Methods The expression of EGFR and NF-ΚB were detected with immunohistochemical staining SP methods in forty-one patients. The radiotherapy effect was assessed by follow up visit and clinical judgement. All of the forty-one patients were divided into three groups: the complete response group,the partial response(or the stable disease)group and the progressive disease group. Result:The ex-pression of EGFR and NF-ΚB were detected in human nasophaTyngeal carcinoma tissues, which were not in normal ones. EGFR and NF-ΚB were significant difference of the radiosensitivity in nasopharyngeal carcinoma tissues (P< 0. 05). The expression of EGFR and NF-ΚB in the complete response-group and the partial response(or the stable disease)-group were lower than the progressive disease-group(P<0. 05),and there was no significant difference between the complete response-group and the partial response(or the stable disease)-group(P>0. 05). The two factors'expression had negative correlation with radiosensitivity. Conclusion: EGFR and NF-ΚB, as important tar-gets, could predict the radiosensitivity of NPC, which could be helpful for targeting treatment and promote the effect of radiotherapy of NPC.