脑梗死患者颈动脉斑块与胆红素和纤维蛋白原水平的研究

目的：研究脑梗死患者颈动脉粥样斑块与胆红素和纤维蛋白原之间的关系。方法：对110例脑梗死住院患者通过颈动脉多普勒超声确定有无颈动脉斑块,根据斑块的有无分为斑块组（72例）和无斑块组（38例）。2组之间性别、年龄比较无显著差异（P〉0．05）。同时测定胆红素和纤维蛋白原水平,调查血糖、血脂及高血压等其他危险因素。结果：斑块组血胆红素,尤其是间接胆红素明显低于无斑块组,有统计学意义（P〈0．05）,纤维蛋白原明显高于无斑块组,有统计学意义（P〈0．05）。结论：低血清胆红素、高纤维蛋白原水平为颈动脉斑块形成和发展的重要危险因素。

Association of carotid plaque with serum bilirubin levels and fibrinogen level in patients with cerebral infarction

Objective：To study the relationship between carotid plaque and serum bilirubin and fibrinogen in the patients with cerebral infarction. Method： 110 in-patients with cerebral infarction were screened for carotid plaque by duplex color Doppler, and then classified into plaque group （n=72） and non-plaque（n=38） groups. No statistical difference in age and gender existed between the 2 groups and in the mean time, the serum bilirubin and fibrinogen were measured, and other possible risk factors for stroke such as serum lipids and glucose, hypertension were investigated. Result： TBIL,IBIL were significantly lower （ P 〈0.05） and FIB was significantly higher （ P 〈0.05）in carotid plaque patients than non-plaque groups. Conclusion： The lower serum bilirubin and the high fibrinogen,are important risk factors for predicting carotid plaque with cerebral infarction.