血清基质金属蛋白酶-9和C反应蛋白与急性冠脉综合征的相关性

目的 研究血清基质金属蛋白酶-9（MMP-9）和C反应蛋白（CRP）与急性冠脉综合征（ACS）的关系。方法选择42例ACS患者、27例SAP患者及25例健康对照,用ELISA法检测血清MMP-9浓度,免疫散射比浊法测定CRP浓度。结果ACS组MMP-9、CRP浓度为（50．64±7．68）ng／ml和（10．24±3．47）mg／L,明显高于SAP组和正常组,差异有统计学意义（P〈0．05）,而SAP组与正常组MMP-9、CRP浓度相比差异无统计学意义（P〉0．05）。结论急性冠脉综合征患者血清基质金属蛋白酶-9（MMP-9）和C反应蛋白（CRP）明显升高。

The relevance of serum matrix metalloproteinase-9 and C-reactive protein to acute coronary syndrome

Objective Study the relationship of serum matrix metalloproteinase- 9 （MMP-9） and C-reactive protein （CRP） with acute coronary syndrome （ACS）. Methods Selected 42 cases of ACS patients and 27 cases of SAP patients to contrasted 25 cases of healthy people. Assay the concentrations of serum MMP-9 by ELISA, and the concentration of CRP were detected by immunoturbidimetry. Results The concentration of MMP-9 and CRP in ACS group was （50.64± 7.68 ） ng/ml and （ 10.24 ± 3.47 ） mg/L, that were much higher than the SAP and normal group, the difference was statistically significant （ P 〈 0.05 ）, but the concentration of MMP-9 and CRP in SAP group compared to that in normal group was no statistically significant （ P 〉 0.05 ）. Conclusion The serum matrix metalloproteinase-9 （ MMP-9 ） and C-reactive protein （CRP） of acute coronary syndrome patients was increased significantly.