Antibody-independent killing of gram-negative bacteria via the classical pathway of complement |
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| Authors: | M Loos F Clas |
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| Affiliation: | 1. State Key Laboratory of Virology and Medical Research Institute, Hubei Province Key Laboratory of Allergy and Immunology and Department of Immunology, Wuhan University School of Basic Medical Sciences, Wuhan 430071, PR China;2. Department of Microbiology, Wuhan University School of Basic Medical Sciences, Wuhan 430071, PR China;3. Hubei Province Cancer Hospital, Wuhan 430079, PR China;4. Biomedical Translational Research Institute, Jinan University, Guangzhou, Guangdong 510630, PR China |
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| Abstract: | ![]()
The experiments in this paper provided evidence that, besides lipopolysaccharides (LPS), porins of gram-negative bacteria bind to C1q and C1. From these experiments, we concluded that the association of LPS and porins (outer membrane proteins, OMP) may potentiate the C1q and C1 binding in the absence of specific antibodies. This antibody independent binding of C1 to LPS and porins is a prerequisite for the activation of the classical pathway of complement leading to the killing of serum-sensitive bacteria. |
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