老年人慢性便秘的药物治疗进展

慢性便秘是老年人最常见的消化道症状之一，不仅影响老年人的生活质量，也存在诱发或加重其他疾病的危险性。老年人慢性便秘的病因复杂，治愈难度大，目前主要是根据便秘的病因、分类及其严重程度进行综合治疗，常见的治疗方法包括调整生活方式、药物治疗、精神心理治疗、手术治疗及生物反馈等。本文针对近年来国内外老年人慢性便秘药物治疗进展，尤其是5-羟色胺受体激动剂、鸟苷酸环化酶c受体激动剂、氯离子通道激活剂、阿片μ受体拮抗剂等新型药物的疗效及安全性进行综述。

Chronic constipation in the elderly: advances in medication treatment

As one of the most common gastrointestinal symptoms in the elderly, chronic constipation （CC） not only affects the seniors＇ life quality, but also aggravates the risk of other diseases. Because of the complicated pathogenesis, CC in the elderly is difficult to cure. At present, comprehensive treatment is mainly based on the causes, classification and severity. Common treatments include adjusting life style, medication, psychological treatment, surgical treatment, biofeedback, etc. In this paper, the recent advances in the medication of CC in the elderly were reviewed, especially on the efficacy and safety of new drugs, such as 5-hydroxytryptamine （5-HT） receptor agonist, guanylate cyclase C agonist, chlorine ion channel activator, mu-opioid receptor antagonist, and so on.