中西医链接治疗小儿肾病综合征120例临床疗效及生活质量评价

目的:观察中西医链接治疗小儿肾病综合征(NS)的临床疗效及生活质量。方法:随机将120例患儿分成治疗组与对照组,分别采用中西医和西医治疗方案。以实验室检查参数和临床症状评分及生活质量问卷得分为指标,观察患儿临床疗效及生活质量。结果:(1)疾病疗效:治疗组总有效率93.33%,对照组总有效率83.33%,两组比较有统计学意义(P<0.05)。(2)治疗前后比较,治疗组与对照组主症均有好转,积分均减少,(P<0.05)均有显著性差异。治疗后两组比较,治疗组与对照组在改善浮肿方面疗效相当,无明显差异(P=0.241>0.05);在治疗蛋白尿、血尿、血浆白蛋白、胆固醇方面治疗组明显优于对照组(P<0.05)有显著性差异。(3)两组患儿在治疗前生活质量积分比较均(P>0.05)无明显差异。治疗后生活质量比较:Z=-4.342,P=0.036<0.05,在生活质量改善方面,治疗组优于对照组。结论:中西医链接治疗小儿肾病综合征疗效确切,优于单纯西药组,改善患儿生活质量优于单纯西医治疗组.

Evaluation of Efficacy and Quality of Life of Chinese and Western Medicine in Treatment of 120 Cases with Children Nephrotic Syndrome

Objective ： To observe the efficacy and the quality of life of pediatric nephrotic syndrome patients treated with tradi- tional Chinese and Western medicine treatment. Methods ：120 cases were randomly divided into treatment group and control group, using Chinese combined with Western medicine and Western medicine treatment respectively. With laboratory examination param- eters and clinical symptom score and quality of life questionnaire score as the indexes, we observed the clinical curative effect and quality of life. Results ： （ 1 ） Disease curative effect ： the total effective rate of treatment group was 93.33 % and that of the control group was 83.33%. The two groups were statistically significant （ P 〈 0.05 ）. （2） After treatment, the treatment group and control group patients had great improvement. And the points were both reduced （P 〈0.05 ） and had significant difference. Compared two groups after treatment, there was no statistical difference on the improving dropsy treatment of the two groups （ P = 0.241 〉 0.05 ）. The treatment group was superior to the control group （P 〈 0.05 ） obviously in the treatment of proteinuria, hematuria, plasma al- bumin and cholesterol. （3） Two groups＇quality of life score before treatment had no obvious differences （ P 〉 0.05 ）. Quality of life after treatment was significantly improved（ Z = 4. 342, P = 0. 036 〈 0.05 ） and the treatment group was better than the control group. Conclusion：TCM and Western medicine have exact therapeutic effect on treating children nephrotic syndrome, better than pure Western medicine group. TCM and Western treatment is better than pure Western therapy.