Slow cholinergic excitation of guinea pig hippocampal neurons is mediated by two muscarinic receptor subtypes |
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| Authors: | W Müller U Misgeld |
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| Affiliation: | 1. Departments of Psychiatry, Neurosciences and Physiology, and the Neuroscience Institute, New York University Langone Medical Center, New York, NY 10016, USA;2. University of Miami, Miller School of Medicine, 1120 NW 14th Street, Room #1324, Miami, FL 33136, USA;3. Department of Medical Neuroscience, Faculty of Medicine, Dalhousie University, Halifax, NS, Canada;4. Department of Pediatrics, Faculty of Medicine, Dalhousie University, Halifax, NS, Canada;5. Department of Physiology and Cell Biology, Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, Beer-Sheva, Israel;6. Neuropathological Institute, University Hospitals Erlangen, Germany;7. Nova Scotia Early Psychosis Program, Department of Psychiatry, Dalhousie University, Halifax, NS, Canada;8. Department of Neurology, University of Campinas, 13083-888 Campinas, Sao Paulo, Brazil;9. Centre for Neuroscience & Regenerative Medicine, Uniformed Services University of the Health Sciences, 12725 Twinbrook Parkway, Rockville, MD 20852, USA;10. Department of Psychiatry, University of Munich, Klinikum rechts der Isar, Ismaninger Strabe 22, D-81675 Munich, Germany;11. Centre for Neural Science, New York University, 4 Washington Place, Room 809, New York, NY 10003, USA;12. University of Pittsburgh, 456 Langley Hall, 4200 Fifth Avenue, Pittsburgh, PA 15269, USA;13. Department of Neurology, Gladstone Institute, 1650 Owens Street, San Francisco, CA 94158-2261, USA;14. Department of Psychiatry, Dalhousie University, Halifax, NS, Canada;15. INSERM U 1129, Hôpital Necker, Paris, Faculty of Medicine, Strasbourg, France;p. Department of Pediatrics, Children''s Hospital of Western Ontario, London, ON, Canada;q. Department of Pharmacology & Toxicology, Anticonvulsant Drug Development Program, University of Utah, Salt Lake City, UT, USA;r. Icahn School of Medicine at Mount Sinai, Department of Neurology, New York, NY, USA;s. Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada;t. Brain Repair Center, Life Science Research Institute, Dalhousie University, Room 229, PO Box 15000, Halifax, NS B3H4R2, Canada;1. School of Environmental Science and Engineering, Sun Yat-Sen University, Guangzhou 510275, China;2. School of Atmospheric Sciences, Sun Yat-Sen University, Guangzhou 510275, China;3. Institute for Environmental and Climate Research Jinan University, Guangzhou 510632, China |
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| Abstract: | ![]()
Stimulation of cholinergic fibers or bath application of carbachol (0.1-10 microM) induced a slow excitability increase in CA3 neurons and dentate granule cells of hippocampal slices. This effect which was antagonized by atropine (1 microM) was mediated by two receptor subtypes: a pirenzepine (10 microM)-insensitive receptor, 'M2', and a pirenzepine (1 microM)-sensitive receptor, 'M1'. The M2-receptor activation led to a blockade of slow afterhyperpolarizations following trains of action potentials and to the occurrence of threshold-activated plateau-depolarizations associated with a conductance increase. The M1-receptor mediated a membrane depolarization sometimes associated with a conductance decrease which reversed its polarity at membrane potentials negative to -80 mV. The 'slow excitatory postsynaptic potential' which results from activation of cholinergic fibers is thus caused by the activation of two receptor subtypes. |
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