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Novel Variants of Clade 2.3.4 Highly Pathogenic Avian Influenza A(H5N1) Viruses,China |
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| Authors: | Min Gu Guo Zhao Kunkun Zhao Lei Zhong Junqing Huang Hongquan Wan Xiaoquan Wang Wenbo Liu Huimou Liu Daxin Peng Xiufan Liu |
| Affiliation: | College of Veterinary Medicine, Yangzhou University, Yangzhou, China (M. Gu, G. Zhao, K. Zhao, L. Zhong, J. Huang, H. Wan, X. Wang, W. Liu, H. Liu, D. Peng, X. Liu); ;Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou (M. Gu, X. Wang, W. Liu, H. Liu, D. Peng, X. Liu) |
| Abstract: | We characterized 7 highly pathogenic avian influenza A(H5N1) viruses isolated from poultry in China during 2009–2012 and found that they belong to clade 2.3.4 but do not fit within the 3 defined subclades. Antigenic drift in subtype H5N1 variants may reduce the efficacy of vaccines designed to control these viruses in poultry. |
| Keywords: | influenza avian influenza virus clade 2.3.4 China clade influenza virus flu H5 H5N1 highly pathogenic viruses avian AIV phylogeny chickens birds HPAI |