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Traumatic life events and its impact on fibromyalgia symptoms through serotonin activity on pain perception and personality traits

Affiliation:	1. Université du Québec en Abitibi-Témiscamingue, 445, boulevard de l’Université, Rouyn-Noranda (Québec) J9X 5E4, Québec, Canada;2. Université du Québec en Abitibi-Témiscamingue, 555, boulevard de l’Université, Drummondville (Québec) J2C 0R5, Québec, Canada;1. University Lille, CHU Lille, ULR 7365 - GRITA - Groupe de Recherche sur les formes Injectables et les Technologies Associées, 59000 Lille, France;2. University Lille, Faculté de pharmacie, U1172–LilNcog - Lille Neuroscience & Cognition, 59000 Lille, France;3. University Lille, Inserm, CHU Lille, U1172–LilNcog - Lille Neuroscience & Cognition, 59000 Lille, France;4. Centre national de ressources et de résilience Lille-Paris (CN2R), 59000 Lille, France;1. Service de psychiatrie B CHU Hèdi Chaker, 3000 Sfax, Tunisie;2. Faculté de médecine de Tunis, 1007 Tunis, Tunisie;1. Department of psychiatry, CHU de Clermont-Ferrand, university of Clermont-Auvergne, CNRS, Clermont-Auvergne INP, Institut Pascal (UMR 6602), Clermont-Ferrand, France;2. Association française de psychiatrie biologique et neuropsychopharmacologie (AFPBN), Paris, France;3. Department of psychiatry, service hospitalo-universitaire, GHU Paris psychiatrie & neurosciences, Paris, France;4. Service de psychiatrie de l’adulte, CIC-1431 Inserm, CHU de Besançon, UR 481 LINC, university Franche-Comté, université Bourgogne Franche-Comté, Fondation FondaMental, Besançon, France;5. Adult psychiatry department, Guillaume-Régnier hospital, university of Rennes 1, centre d’investigation clinique CIC Inserm 1414, Rennes university hospital, Rennes, France;6. Bipolar and depressive disorders unit, institute of neuroscience, hospital clinic, university of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Espagne;7. Pôle de psychiatrie, INT-UMR7289, CNRS Aix-Marseille université, Assistance publique–Hôpitaux de Marseille, Marseille, France;1. Paris Brain Institute – Institut du Cerveau (ICM), Sorbonne University/CNRS/Inserm, Paris, France;2. Department of philosophy, Sciences Normes Démocratie research unit, Sorbonne university/CNRS, Paris, France;3. Department of psychiatry, DMU Neuroscience, Pitié-Salpêtrière hospital, Sorbonne university/Assistance publique–Hôpitaux de Paris (AP–HP), Paris, France

Abstract:	Fibromyalgia is a chronic syndrome characterized by widespread muscular pain and tenderness with no evidence of soft tissue inflammation. Early-life stressors and traumatic events have been described to increase the risk of developing a number of psychiatric conditions, and conditions related to chronic pain in later life such as fibromyalgia on the other hand. In this overview of the literature on the topic, we present the impact that traumatic life events can have on fibromyalgia symptoms through serotonin activity on pain perception and personality traits.

Keywords:	Traumatic life events Fibromyalgia Serotonin Pain perception Personality traits
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