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Lack of MERS Coronavirus Neutralizing Antibodies in Humans,Eastern Province,Saudi Arabia |
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| Authors: | Stefanie Gierer Heike Hofmann-Winkler Waleed H. Albuali Stephanie Bertram Abdullah M. Al-Rubaish Abdullah A. Yousef Awatif N. Al-Nafaie Amein K. Al-Ali Obeid E. Obeid Khaled R. Alkharsah Stefan P?hlmann |
| Affiliation: | German Primate Center, Göttingen, Germany (S. Gierer, H. Hofmann-Winkler, S. Bertram, S. Pöhlmann); ;University of Dammam, Dammam, Saudi Arabia (W.H. Albuali, A.M. Al-Rubaish, A.A. Yousef, A.N. Al-Nafaie, A.K. Al-Ali, O.E. Obeid, K.R. Alkharsah). |
| Abstract: | We used a lentiviral vector bearing the viral spike protein to detect neutralizing antibodies against Middle East respiratory syndrome coronavirus (MERS-CoV) in persons from the Eastern Province of Saudi Arabia. None of the 268 samples tested displayed neutralizing activity, which suggests that MERS-CoV infections in humans are infrequent in this province. |
| Keywords: | MERS coronavirus neutralizing antibodies Saudi Arabia spike pseudotyping MERS-CoV viruses coronavirus Middle East respiratory syndrome coronavirus seroprevalence serum plasma respiratory infections |