Reviving through human hippocampal newborn neurons |
| |
| Institution: | 1. CESP, MOODS Team, Inserm, faculté de pharmacie, université Paris-Saclay, 92296 Châtenay-Malabry, France;2. CESP, MOODS Team, Inserm, faculté de médecine, université Paris-Saclay, 94275 Le Kremlin-Bicêtre, France;3. Service hospitalo-universitaire de psychiatrie de Bicêtre, hôpital de Bicêtre, hôpitaux universitaires Paris-Saclay, Assistance publique–Hôpitaux de Paris, 94275 Le Kremlin-Bicêtre, France;4. Department of Psychiatry, Columbia University, New York, NY 10032, USA;5. Division of Systems Neuroscience, Research Foundation for Mental Hygiene, Inc (RFMH)/New York State Psychiatric Institute (NYSPI), New York, NY 10032, USA;6. Department of Neuroscience, Columbia University, New York, NY 10032, USA;1. Centre psychothérapique de Nancy, CHRU Nancy, 25, rue Lionnois, 54000 Nancy, France;2. CHS Ravenel, 1115, avenue René-Porterat, 88500 Mirecourt, France;3. Pôle de psychiatrie et psychologie clinique, centre psychothérapique de Nancy, 1, rue Docteur-Archambault, 54520 Laxou, France;4. Université de Lorraine, CHRU Nancy, 25, rue Lionnois, 54000 Nancy, France;5. Fondation santé des étudiants de France, Paris, France;1. Paris Brain Institute – Institut du Cerveau (ICM), UMR 7225/UMRS 1127, CNRS / INSERM, Sorbonne university, Paris, France;2. Sorbonne University, Department of Philosophy, SND Research Unit, UMR 8011, CNRS, Paris, France;3. Department of psychiatry, Pitié-Salpêtrière hospital, DMU Neuroscience, Sorbonne university, Assistance publique–Hôpitaux de Paris (AP–HP), Paris, France;1. Pôle hospitalo-universitaire de psychiatrie d’adultes du Grand Nancy, centre psychothérapique de Nancy, 1, rue du Docteur Archambault, 54521 Laxou, France;2. Maison des addictions, CHRU Nancy, Nancy, France;3. Unité de méthodologie, DRCI, BIOBASE, département MPI, data management et statistique UMDS, CHRU-Nancy, 54000 Nancy, France;4. Université de Lorraine, Faculté de Médecine, Département du Grand Est de Recherche en Soins Primaires : DEGERESP, 54000 Nancy, France;5. CNRS, IECL, université de Lorraine, 54000 Nancy, France;6. IADI, U1254, INSERM, Université de Lorraine, CHRU de Nancy Brabois, Nancy, France;7. Inserm U1114, fédération de médecine translationnelle de Strasbourg, département de psychiatrie, centre hospitalier régional universitaire de Strasbourg, 67000 Strasbourg, France;1. Université de Bordeaux, 121, rue de la Béchade 33076 Bordeaux cedex, France;2. Equipe phénoménologie et déterminants des comportements appétitifs, Sanpsy CNRS USR 3413, 121, rue de la Béchade 33076 Bordeaux Cedex, France;3. Filière Addictologie, CH Cadillac, 89, rue Cazeaux-Cazalet, 33410 Cadillac, France;4. Pôle interétablissement d’addictologie et filière régionale hospitalo-universitaire, CH Charles-Perrens et CHU de Bordeaux, 121, rue de la Béchade 33076 Bordeaux Cedex, France;5. Center for studies of addiction, department of psychiatry, Perelman school of medicine, university of Pennsylvania, Phildelphia, PA, États-Unis;1. Department of Nursing, Faculty of Health Sciences, Firat University, Elazi?, Turkey;2. Department of Nursing, Faculty of Health Sciences, Siirt University, Siirt, Turkey;3. Department of Nursing, Faculty of Health Sciences, Istanbul Sabahattin Zaim University, Istanbul, Turkey;4. Firat University Hospital, Elazi?, Turkey |
| |
| Abstract: | Recent contradictory data has renewed discussion regarding the existence of adult hippocampal neurogenesis (AHN) in humans, i.e., the continued production of new neurons in the brain after birth. The present review revisits the debate of AHN in humans from a historical point of view in the face of contradictory evidence, analyzing the methods employed to investigate this phenomenon. Thus, to date, of the 57 studies performed in humans that we reviewed, 84% (48) concluded in favor of the presence of newborn neurons in the human adult hippocampus. Besides quality of the tissue (such as postmortem intervals below 26 hours as well as tissue conservation and fixation), considerations for assessing and quantify AHN in the human brain require the use of stereology and toxicological analyses of clinical data of the patient. |
| |
| Keywords: | Adult hippocampal neurogenesis in humans Neuron Controversy |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
