Topic use of Annona crassiflora Mart. contributes to wound healing due to the antioxidant and proliferative effects of fibroblasts |
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| Institution: | 1. Biomedical Sciences Institute, Federal University of Uberlândia, 38400-902 Uberlândia-MG, Brazil;2. Biology Institute, State University of Campinas, 13083-862 Campinas-SP, Brazil;3. Biotechnology Institute, Federal University of Uberlândia, 38405-319 Uberlândia-MG, Brazil;4. Laboratory of Experimental Pathology, Federal University of São João del-Rei, 35501-296 Divinópolis-MG, Brazil;1. St. Joseph University, Dept. of Orthopedic Surgery, Hotel Dieu de France Hospital, Alfred Naccache Blvd, Beirut, Lebanon;2. Foothills Medical Center, Department of Surgery, University of Calgary, Canada;3. 0490 McCaig Tower, Foothills Medical Center, 3134 Hospital Dr NW, Calgary, Alberta T2N 5A1, Canada;1. Penn State College of Medicine, Hershey, PA, 17033 USA;2. Department of Orthopaedics and Rehabilitation, Penn State Hershey Medical Center, Hershey, PA, 17033 USA;3. Public Health Sciences, Penn State College of Medicine, Hershey, PA, 17033 USA;4. Department of Anesthesiology, University of Utah, Salt Lake City, UT, 84132 USA;1. Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Usak University, Usak, Turkey;2. Department of Prosthodontics, Faculty of Dentistry, Usak University, Usak, Turkey;3. Department of Pathology, Faculty of Veterinary Medicine, Burdur Mehmet Akif Ersoy University, Burdur, Turkey;4. Department of Periodontology, Faculty of Dentistry, Usak University, Usak, Turkey;5. Mamak Oral Healt Center, Ankara, Turkey;1. Department of Spine surgery, The Ningbo No.6 Hospital, Ningbo, 315040, Zhejiang Province, China;2. Medical School of Ningbo University, Ningbo, 315040, Zhejiang Province, China;1. Shenzhen University General Hospital, Shenzhen 518060, China;2. Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Shenzhen University Health Science Center, Shenzhen 518060, China.;3. The Department of Orthopedics, The Second Affiliated Hospital of Air Force Medical University, Xi''an 710000, China.;1. William Beaumont Army Medical Center, Department of Orthopaedic Surgery, El Paso, Texas, USA;2. Texas Tech University Health Science Center, Department of Orthopaedic Surgery, El Paso, Texas, USA;3. Uniformed Services University, Clinical and Experimental Orthopedics, Bethesda, Maryland, USA;4. Carthage Area Hospital, Department of Orthopaedic Surgery, Carthage, NY, USA |
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| Abstract: | Annona crassiflora Mart. is a species native to the Cerrado biome, whose fruit is known as araticum or marolo. Plant parts are widely used in folk medicine to treat inflammation and pain associated with rheumatism, wounds, venereal diseases, snakebites, and microbial infections. Thus, we investigated a fraction rich in phenolic compounds (PCAc) obtained from the crude extract of the peel of these fruits on non-cytotoxic, anti-inflammatory, antioxidant, and collagen biosynthesis properties in the healing of wounds induced on the back of BALB/c mice. For the control group, the induced wounds were not treated and for the others, wounds were treated topically with vehicle or vehicle plus PCAc. Both fractions contained in PCAc demonstrated effective protection on fibroblasts. We highlight the effect of the ethyl acetate fraction which, in addition to the protective effect, has a proliferative activity on these cells. In addition, PCAc caused improvement in healing after 7 days of treatment and in the longest period of treatment with PCAc (7, 14, and 21 days) there was a greater contraction of the wound, accompanied by resolution of the inflammatory process, antioxidant defense, increasing collagen synthesis, and modulation of metalloproteinases. PCAc demonstrated better re-epithelialization and organization of the dermis at the end of treatment. The changes promoted by the phenolic compounds of A. crassiflora were important in the healing process, especially in activities related to inflammation, oxidative stress, and fibrogenesis. |
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