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Ezh2 and Runx1 Mutations Collaborate to Initiate Lympho-Myeloid Leukemia in Early Thymic Progenitors
Authors:Christopher A.G. Booth  Nikolaos Barkas  Wen Hao Neo  Hanane Boukarabila  Elizabeth J. Soilleux  George Giotopoulos  Noushin Farnoud  Alice Giustacchini  Neil Ashley  Joana Carrelha  Lauren Jamieson  Deborah Atkinson  Tiphaine Bouriez-Jones  Rab K. Prinjha  Thomas A. Milne  David T. Teachey  Elli Papaemmanuil  Brian J.P. Huntly  Adam J. Mead
Affiliation:1. Haematopoietic Stem Cell Biology Laboratory, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DS, UK;2. MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DS, UK;3. Division of Cellular and Molecular Pathology, Department of Pathology, University of Cambridge, Cambridge, UK;4. Wellcome Trust-MRC Cambridge Stem Cell Institute, Cambridge, UK;5. Department of Haematology, University of Cambridge, Cambridge, UK;6. Cambridge Institute for Medical Research, Cambridge Biomedical Campus, Hills Road, Cambridge CB2 0XY, UK;7. Center for Molecular Oncology, Center for Heme Malignancies and Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA;8. Department of Cell and Developmental Biology, University College London, London WC1E 6BT, UK;9. Epigenetics DPU, Oncology and Immuno-Inflammation Therapy Area Units, GlaxoSmithKline, Stevenage, UK;10. Division of Oncology, Children''s Hospital of Philadelphia and Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA;11. Center for Hematology and Regenerative Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, SE-141 86 Stockholm, Sweden;12. Department of Cell and Molecular Biology, Karolinska Institutet, SE-171 77 Stockholm, Sweden;13. NIHR Biomedical Research Centre, Churchill Hospital, Oxford OX3 7LE, UK
Abstract:
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  • Keywords:early thymic progenitors  early thymic progenitor leukemia  leukemic stem cells  leukemia propagating cells  EZH2  RUNX1  FLT3-ITD  BET inhibition
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