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ANALYSIS OF SUXAMETHONIUM SENSITIVITY FOLLOWING TERMINATION OF PREGNANCY |
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| Authors: | WHITTAKER, M. BRITTEN, J. J. |
| Affiliation: | Department of Chemistry, University of Exeter EX4 4QD. Department of Anaesthetics, Royal Postgraduate Medical School, Hammersmith Hospital London W12 OHS |
| Abstract: | The choiinesterase genotypes in the majority (25135) of patientswith suxamethonium sensitivity foilowing termination of pregnancyare heterozygotes with an Exa gene. Tweive of these patientshave the genotype EXUE{. The reported duration of apnoea isminimal in the heterozygotes iacking the Exa gene (about 510min) and maximal in the homozygotes EfEf (about 35 min). Withfew exceptions, the heterozygotes having an E1a gene are apnoeicfor 1015 min. The apparent low frequency of suxamethoniumin these patients is discussed. |
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