血清骨因子水平与冠心病患者冠状动脉病变程度相关性研究

目的探讨冠心病患者血清骨保护素(OPG)、骨桥蛋白(OPN)、骨钙素等骨因子水平与冠心病患者冠状动脉病变程度的关系。方法选取西部战区总医院就诊的患者103例,其中冠状动脉造影示血管狭窄程度<50%者50例为对照组,稳定性冠心病患者53例,根据Gensini评分将冠心病患者分为高分组(Gensini评分≥20分)24例和低分组(Gensini评分<20分)29例。收集患者一般临床资料,检测血清OPG、OPN、骨钙素水平。结果 3组HDL-C水平比较,差异有统计学意义(P<0.05)。高分组OPG、OPN水平明显高于低分组和对照组,骨钙素水平明显低于低分组和对照组(P<0.05);低分组骨钙素水平明显低于对照组(P<0.05)。冠心病患者血清OPG、OPN水平与Gensini评分呈正相关(r=0.819,P=0.018;r=0.367,P=0.007),血清骨钙素水平与Gensini评分呈负相关(r=-0.318,P=0.020)。logistic回归分析显示,OPG、OPN是冠心病的危险因素,骨钙素是冠心病的保护因素(P<0.05);OPG、OPN是Gensini评分增高的危险因素,骨钙素是Gensini评分增高的保护因素(P<0.05)。结论稳定性冠心病患者血清OPG、OPN、骨钙素的水平与冠状动脉病变的严重程度密切相关。

Relationship between serum bone factor Levels and coronary artery lesions in coronary heart disease patients

Objective To study the relationship of serum osteoprotegerin,osteopontin and osteocalcin levels with coronary artery lesions in CHD patients.Methods One hundred and three patients who visited the Western Theater General Hospital were divided into control group(n=53),Gensini score ≥20 group(n=24) and Gensini score <20 group(n=29).Their clinical data were recorded and their serum osteoprotegerin,osteopontin and osteocalcin levels were measured.Results The serum HDL-C level was significantly different in 3 groups(P<0.05).The serum levels of osteoprotegerin and osteopontin were significantly higher while those of osteocalcin were significantly lower in Gensini score ≥20 group than in Gensini score <20 group and control group(P<0.05).The serum osteocalcin levels were significantly lower in Gensini score <20 group than in control group(P<0.05).The serum levels of osteoprotegerin and osteopontin were positively related with the Gensini score while the those of osteocalcin were negatively related with the Gensini score in CHD patients(r=0.819,P=0.018;r=0.367,P=0.007;r=-0.318,P=0.020).Logistic regression analysis showed that osteoprotegerin and osteopontin were the risk factors for CHD and elevated Gensini score while osteocalcin was the protective factor for CHD and elevated Gensini score(P<0.05).Conclusion Serum osteoprotegerin,osteopontin and osteocalcin levels are closely related with coronary artery lesions in CHD patients.