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Effects of ZD7288 on firing pattern of thermosensitive neurons isolated from hypothalamus
Authors:Cai Chunqing  Meng Xiaojing  He Junchu  Wu Hangyu  Zou Fei
Affiliation:Department of Occupational Health and Occupational Medicine, School of Public Health and Tropical Medicine, Southern Medical University, Guangzhou, China
Abstract:
The role of the hyperpolarization-activated current (Ih) mediated by HCN channels in temperature sensing by the hypothalamus was addressed. In warm-sensitive neurons (WSNs), exposure to ZD7288, an inhibitor of Ih mediated by hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, decreased their action potential amplitudes and frequencies significantly. By contrast, ZD7288 had little or no effect on temperature-insensitive neurons (TINs). Exposure of WSNs to ZD7288 led to a significant increase in the duration of the inter-spike interval and a reduction of Ih irreversibly. These results suggest that ZD7288 have the contrasting effects on the firing patterns of WSNs versus TINs, which implies HCN channels play a central role in temperature sensing by hypothalamic neurons.
Keywords:HCN, hyperpolarization-activated cyclic nucleotide-gated   WSNs, warm-sensitive neurons   TINs, temperature-insensitive neurons   PO/AH, the preoptic and anterior hypothalamus   ISI, interspike interval   Ih, hyperpolarization-activated current   AP, action potential   AHP, after-hyperpolarization
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