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Influence of GRIA1, GRIA2 and GRIA4 polymorphisms on diagnosis and response to antipsychotic treatment in patients with schizophrenia |
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| Authors: | Crisafulli Concetta Chiesa Alberto De Ronchi Diana Han Changsu Lee Soo-Jung Park Moon Ho Patkar Ashwin A Pae Chi-Un Serretti Alessandro |
| Affiliation: | a Department of Biomorphology and Biotechnologies, Division of Biology and Genetics, University of Messina, Italy b Institute of Psychiatry, University of Bologna, Bologna, Italy c Department of Psychiatry, College of Medicine, Korea University, Ansan, Kyounggi-Do, Republic of Korea d Department of Psychiatry, Bucheon St. Mary's Hospital, The Catholic University of Korea College of Medicine, Bucheon, Kyounggi-Do, Republic of Korea e Department of Neurology, College of Medicine, Korea University, Ansan, Kyounggi-Do, Republic of Korea f Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA |
| Abstract: | The present study is aimed at exploring whether some single nucleotide polymorphisms (SNPs) within GRIA1, GRIA2 and GRIA4 could be associated with schizophrenia and whether they could predict clinical outcomes in Korean in-patients treated with antipsychotics. One hundred forty five patients with MD, 221 in-patients with schizophrenia and 170 psychiatrically healthy controls were genotyped for 17 SNPs within GRIA1, GRIA2 and GRIA4. Baseline and final clinical measures, including the Positive and Negative Symptoms Scale (PANSS), were recorded. No significant association was found with the diagnosis of schizophrenia. We observed an association between rs3813296 genotype and improvement on PANSS negative scores. Our findings provide no evidence for an association between SNPs within GRIA1, GRIA2 and GRIA4 under investigation and schizophrenia susceptibility, although rs3813296 (GRIA2) could be associated with improvement on PANSS negative scores. However, taking into account the several limitations of our study, further research is needed to draw more definitive conclusions. |
| Keywords: | Glutamate receptors GRIA1 GRIA2 GRIA4 Schizophrenia Antipsychotics |
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