| 炮制时间对何首乌16个成分含量变化影响的研究 |
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| 引用本文： | 赵梦杰,龚小红,党珏,袁岸,李燕,罗林,刘美辰,李芸霞.炮制时间对何首乌16个成分含量变化影响的研究[J].中国中药杂志,2017,42(7):1344-1349. |
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| 作者姓名： | 赵梦杰 龚小红 党珏 袁岸 李燕 罗林 刘美辰 李芸霞 |
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| 作者单位： | 成都中医药大学 药学院 教育部中药材标准化重点实验室 中药资源系统研究与开发利用省部共建国家重点实验室培育基地, 四川 成都 611137,成都中医药大学 药学院 教育部中药材标准化重点实验室 中药资源系统研究与开发利用省部共建国家重点实验室培育基地, 四川 成都 611137,成都中医药大学 药学院 教育部中药材标准化重点实验室 中药资源系统研究与开发利用省部共建国家重点实验室培育基地, 四川 成都 611137,成都中医药大学 药学院 教育部中药材标准化重点实验室 中药资源系统研究与开发利用省部共建国家重点实验室培育基地, 四川 成都 611137,成都中医药大学 药学院 教育部中药材标准化重点实验室 中药资源系统研究与开发利用省部共建国家重点实验室培育基地, 四川 成都 611137,成都中医药大学 药学院 教育部中药材标准化重点实验室 中药资源系统研究与开发利用省部共建国家重点实验室培育基地, 四川 成都 611137,成都中医药大学 药学院 教育部中药材标准化重点实验室 中药资源系统研究与开发利用省部共建国家重点实验室培育基地, 四川 成都 611137,成都中医药大学 药学院 教育部中药材标准化重点实验室 中药资源系统研究与开发利用省部共建国家重点实验室培育基地, 四川 成都 611137 |
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| 基金项目： | 中国科技部和澳门科学技术发展基金项目（007/2014/AMJ）；中药质量研究国家重点实验室开放基金项目（009）；中国国家自然科学基金项目（81373943，81573583）；四川青年科学技术基金项目（2013JQ0018）；四川省科技厅青年科技创新研究团队项目（2017TD0001，2015TD0028，2016TD0006） |
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| 摘 要： | 为研究48 h的炮制时间对何首乌中成分的含量及变化影响。采用HPLC测定22个不同炮制时间的何首乌对比市售制首乌中各成分的含量,并采用指纹图谱相似性分析和聚类分析对测定结果进行特征分析。结果显示,相似度均在0.9~1.0,各个样本之间有较好的相关性。聚类分析方法将22个制首乌和生首乌样品基本按成分变化特征聚为4类。该研究发现4~5 h为何首乌最佳炮制时间,为何首乌的质量控制以及深入研究提供参考依据。
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| 关 键 词： | 何首乌 炮制时间 相似性分析 聚类分析 |
| 收稿时间： | 2016/12/7 0:00:00 |
Effect of processing time of Polygoni Multiflori Radix on content changes of 16 componens |
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| ZHAO Meng-jie,GONG Xiao-hong,DANG Jue,YUAN An,LI Yan,LOU Lin,LIU Mei-chen and LI Yun-xia.Effect of processing time of Polygoni Multiflori Radix on content changes of 16 componens[J].China Journal of Chinese Materia Medica,2017,42(7):1344-1349. |
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| Authors: | ZHAO Meng-jie GONG Xiao-hong DANG Jue YUAN An LI Yan LOU Lin LIU Mei-chen and LI Yun-xia |
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| Institution: | The Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicine, State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources Co-founded by Sichuan Province and Ministry of Science and Technology of the People''s Republic of China Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China,The Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicine, State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources Co-founded by Sichuan Province and Ministry of Science and Technology of the People''s Republic of China Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China,The Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicine, State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources Co-founded by Sichuan Province and Ministry of Science and Technology of the People''s Republic of China Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China,The Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicine, State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources Co-founded by Sichuan Province and Ministry of Science and Technology of the People''s Republic of China Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China,The Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicine, State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources Co-founded by Sichuan Province and Ministry of Science and Technology of the People''s Republic of China Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China,The Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicine, State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources Co-founded by Sichuan Province and Ministry of Science and Technology of the People''s Republic of China Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China,The Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicine, State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources Co-founded by Sichuan Province and Ministry of Science and Technology of the People''s Republic of China Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China and The Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicine, State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources Co-founded by Sichuan Province and Ministry of Science and Technology of the People''s Republic of China Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China |
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| Abstract: | To study 48 h processing time of Polygoni Multiflori Radix on its contents and changes of chemical components. HPLC was used to determine the contents of various components in 22 Polygoni Multiflori Radix samples with different processing time, and then the fingerprint similarity analysis and clustering analysis were used for characteristics analysis. Results showed that the similarity was between 0.9-1.0, with good correlation between the samples. In the clustering analysis, the 22 Polygoni Multiflori Radix and processed Polygoni Multiflori Radix samples were classified into 4 types according to the composition changes. The results demonstrated that 4-5 h was the best processing time, providing references for quality control and further study of Polygoni Multiflori Radix. |
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| Keywords: | Polygoni Multiflori Radix processing time similarity analysis clustering analysis |
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