A double blind, placebo-controlled study to assess the effect of famciclovir on virus replication in patients with chronic hepatitis B virus infection |
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| Authors: | J. Main J. L. Brown C. Howells R. Galassini M. Crossey P. Karayiannis P. Georgiou G. Atkinson H. C. Thomas |
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| Affiliation: | Department of Medicine, St Mary's Hospital Medical School, London;SmithKline Beecham Pharmaceuticals, New Frontiers Science Park (South), Harlow, Essex, UK |
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| Abstract: | SUMMARY. This is the first double-blind controlled study of famciclovir, an oral antiviral agent, as potential therapy for chronic hepatitis B virus (HBV) carriers. A fall of more than 90% in HBV DNA levels was noted in six of 11 evaluable patients treated with a 10 day course of oral famciclovir. Further studies with more prolonged therapy are ongoing. |
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| Keywords: | famciclovir hepatitis B virus nucleoside analogue |
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