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| 高同型半胱氨酸血症与Alzheimer病的关系 | |
| 引用本文： | 高平,秦绍森,肖路延,蔡晓杰. 高同型半胱氨酸血症与Alzheimer病的关系[J]. 中国神经免疫学和神经病学杂志, 2005, 12(3): 125-127 |
| 作者姓名： | 高平 秦绍森 肖路延 蔡晓杰 |
| 作者单位： | 1. 卫生部北京医院,神经内科,北京,100730 2. 卫生部北京医院,检验科,北京,100730 |
| 摘 要： | 目的 探讨高同型半胱氨酸血症与Alzheimer病(AD)的关系。方法 对38例AD患者及30例对照组老年人进行血浆同型半胱氨酸(Hcy)测定，并分析Hcy与认知功能障碍、痴呆严重程度、痴呆病程及精神症状的关系。结果 AD组血浆Hcy显著高于对照组IHcy水平与认知功能障碍、痴呆严重度密切相关，与痴呆病程和精神症状无关。结论 高同型半胱氨酸血症可能参与AD发病机制。 |
| 关 键 词： | 同型半胱氨酸 Alzheimer病 认知功能障碍 发病机制 |
| 文章编号： | 1006-2963(2005)03-0125-03 |
| 修稿时间： | 2005-01-10 |
The Association of Hyperhomocysteine and Alzheimer Disease |
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| GAO Ping,QIN Shao-sen,XIAO Lu-yan,CAI Xiao-jie. The Association of Hyperhomocysteine and Alzheimer Disease[J]. Chinese Journal of Neuroimmunology and Neurology, 2005, 12(3): 125-127 | |
| Authors: | GAO Ping QIN Shao-sen XIAO Lu-yan CAI Xiao-jie |
| Affiliation: | GAO Ping1,QIN Shao-sen1,XIAO Lu-yan2,CAI Xiao-jie1 |
| Abstract: | Objective To investigate the correlation between of hyperhomocysteine and Alzheimer disease (AD). Methods Plasma homocysteine (Hcy) concentration was measured in 38 patients with AD and 30 control cases. The correlation between plasma homocysteine levels and cognitive impairment and severity of dementia in AD patients, psychotic symptoms, duration of dementia were analyzed. Results Serum Hcy levels were significantly higher in AD group than that in control one. There was a significantly correlation between Hcy levels and cognitive decline and severity of dementia. Hcy levels were not correlated to the duration of dementia. No significantly difference was found in Hcy between patients with and without hallucination and delusion. Conclusions Hyperhomocysteine may lake part in the pathogenesis of AD. |
| Keywords: | Homocystenine Alzheimer disease cognitive impairment pathogenesis |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |