MicroRNA in lung cancer |
| |
| Authors: | P-Y Lin S-L Yu P-C Yang |
| |
| Affiliation: | 1.Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan;2.Department of Internal Medicine, National Taiwan University Hospital, No. 7, Chung-Shan South Road, Taipei 100, Taiwan;3.Department of Clinical and Laboratory Sciences and Medical Biotechnology, National Taiwan University, Taipei, Taiwan;4.Division of Genomic Medicine, Research Center for Medical Excellence, National Taiwan University, Taipei, Taiwan |
| |
| Abstract: | ![]()
MicroRNAs (miRNAs) are small non-protein-coding RNAs that function as endogenous negative gene regulators. Dysfunctions of miRNAs are frequently found in malignancies, including lung cancer. In this review, we summarise the current understanding of miRNAs in lung cancer tumourigenesis, and highlight their potential in overcoming drug resistance, abetting histological sub-classification techniques, and serving as biomarkers for lung cancer risk stratification and outcome prediction. |
| |
| Keywords: | lung cancer microRNA oncogene tumour suppressor risk stratification personalised medicine |
|
|
