| 溪黄草甲素的结构研究 |
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| 引用本文： | 金人玲,程培元,徐光漪.溪黄草甲素的结构研究[J].药学学报,1985,20(5):366-371. |
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| 作者姓名： | 金人玲 程培元 徐光漪 |
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| 作者单位： | 南京药物研究所
(金人玲，程培元)，上海医药工业研究院(徐光漪) |
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| 摘 要： | 从溪黄草Rabdosia serra(Maxim.)Hara干叶、茎中共分得八个化合物,其中化合物Ⅲ～Ⅷ经鉴定分别为excisanin A(Ⅲ),kamebakaurin(Ⅳ),2α-羟基乌苏酸(Ⅴ),β-谷甾醇(Ⅵ),乌苏酸(Ⅶ)和β-谷甾醇D-葡萄糖甙(Ⅷ)。Ⅰ为新化合物,经光谱分析和衍生物制备证明其结构为1,14-二羟基,7,20,19,20-二环氧-16-贝壳杉烯-15-酮,命名为溪黄草甲素。药理实验表明化合物Ⅰ,Ⅲ和Ⅳ对Hela细胞具有显著的抑制作用。
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| 关 键 词： | 溪黄草 溪黄草甲素 尾叶香茶菜甲素 Kamebakaurin |
| 收稿时间： | 1984-04-11 |
THE STRUCTURE OF RABDOSERRIN A,ISOLATED FROM RABDOSIA SERRA (MAXIM) HARA |
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| JIN Ren-Ling,CHENG Pei-Yuan and XU Guang-Yi.THE STRUCTURE OF RABDOSERRIN A,ISOLATED FROM RABDOSIA SERRA (MAXIM) HARA[J].Acta Pharmaceutica Sinica,1985,20(5):366-371. |
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| Authors: | JIN Ren-Ling CHENG Pei-Yuan and XU Guang-Yi |
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| Abstract: | Eight constituents were isolated from the leaves and stem of Rabdosia serra (Maxim) Hara, one of them is a new diterpenoid named rabdoserrin A (Ⅰ). Its structure was confirmed as ent-1,14-dihydroxy-7,20; 19,20-diepoxy(1a, 4a, 7a, 14R, 20R)-kaur-16-en-15-one by spectroscopic and chemical methods. Six known compounds were identified as excisanin A (Ⅲ), kamebakaurin (Ⅳ), 2α, 3β-dihydroxy-urs-12-en-28-oic acid (Ⅴ),β-sitosterol (Ⅵ), ursolic acid (Ⅶ) and β-sitosterolglucoside (Ⅷ), respectively. (Ⅰ), (Ⅲ) and (Ⅳ;) showed in vitro cytotoxicity against cultured Hela cells. |
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| Keywords: | Rabdosia serra (Maxim) Hara Rabdoserrin A Excisanin A Kamebakaurin |
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