间硝苯啶、硝苯啶与尼群的平对动物降压作用的比较性研究

在清醒正常血压大鼠、免以及肾型高血压大鼠,比较了m-nif、nif及nitr的降压强度,和降压的时间动态过程,三药的降压作用与对照组及自身前后对比,统计学上均非常显著。m-nif与nitr降压持续时间较nif长。从清醒正常血压大鼠降压的量效关系比较,m-nif、nif和nitr的ED₅₀)分别为33.7±3.4,45.6±3.6和51.2±4.1 mg/kg(即90±9,132±10,142±11μmol/kg)。按克分子量计算对比m-nif的降压强度最大,nitr最弱。但三药对正常血压及肾型高血压动物的降压作用,按组间对比,无统计学差异。

COMPARATIVE STUDIES ON THE ANTIHYPERTENSIVE EFFECTS OF M-NIFEDIPINE,NIFEDIPINE AND NITRENDIPINE IN CONSCIOUS RATS AND RABBITS

m-Nifedipine (m-nif) is a new vasodilatory calcium antagonist with pronounced hypotensive action. A comparative study on the antihypertensive effects of m-nif, nifedipine (nif) and nitrendipine (nitr) in consciou rats, rabbits and renal hypertensive rats were carried out. Systolic blood pressure of rats was measured on the tail. The systolic and diastolic blood pressure of rabbits were measured directly from the common carotid artery. The hypotensive effects of m-nif, nil and nitr (rats 10 mg/kg; rabbits 8 mg/kg po) were studied on both animals. Peak effect was observed 4 h after oral administration in rats and 1 h in rabbits. The effects declined between 6-8 h after treatment in rats and 4～8 h in rabbits. The blood pressure returned to their initial values 24 h after administration. A quantitative comparison between the maximal % (4 h after medication) reduction of blood pressure was made by regression analysis. The E₅₀ values of m-nil, nil and nitr were found to be 33.7±3.4, 45.58±3.6 and 51.2±4.1mg/kg (90±9, 132±10, 142±11 μmol/kg) respectively. In renal hypertensive rats, m-nif, nil and nitr at the same dose of 10 mg/kg po significantly reduced blood pressure 4 h after administration.