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| Association of HLA-B 1502 and 1511 Allele with Antiepileptic Drug-induced Stevens-Johnson Syndrome in Central China简 | |
| 引用本文： | 孙丹,余春华,刘智胜,何雪莲,胡家胜,吴革菲,毛冰,吴舒华,项慧慧. Association of HLA-B 1502 and 1511 Allele with Antiepileptic Drug-induced Stevens-Johnson Syndrome in Central China简[J]. 华中科技大学学报(医学英德文版), 2014, 34(1): 146-150. DOI: 10.1007/s11596-014-1247-7 |
| 作者姓名： | 孙丹 余春华 刘智胜 何雪莲 胡家胜 吴革菲 毛冰 吴舒华 项慧慧 |
| 作者单位： | [1]Department of Pediatric Neurology, Wuhan Children’s Hospital, Wuhan 430016, China [2]Department of Science Research and Education, Wuhan Children＇s Hospital, Wuhan 430016, China [3]Department of Central Laboratory, Wuhan Children＇s Hospital, Wuhan 430016, China |
| 基金项目： | supported by a grant from Clinical Scientific Research of Wuhan Sanitary Bureau（No.WX11C26）; research fund from Janssen Research Council of China（No.JRCC2011-01） |
| 摘 要： | Previous studies have demonstrated a strong association between carbamazepine（CBZ）-induced Stevens-Johnson syndrome（SJS） and HLA-B 1502 in Han Chinese. Here, we extended the study of HLA-B 1502 susceptibility to two different antiepileptic drugs, oxcarbazepine（OXC） and phenobabital（PB）. In addition, we genotyped HLA-B 1511 in a case of CBZ-induced SJS with genotype negative for HLA-B 1502. The presence of HLA-B 1502 was determined using polymerase chain reaction with sequence-specific primers（PCR-SSP）. Moreover, we genotyped HLA-B 1502 in 17 cases of antiepileptic drugs（AEDs）-induced cutaneous adverse drug reactions（cADRs）, in comparison with AEDs-tolerant（n=32） and normal controls（n=38） in the central region of China. The data showed that HLA-B 1502 was positive in 5 of 6 cases of AEDs-induced SJS（4 CBZ, 1 OXC and 1 PB）, which was significantly more frequent than AEDs-tolerant（2/32, 18 CBZ, 6 PB and 8 OXC） and normal controls（3/38）. Compared with AEDs-tolerant and normal controls, the OR for patients carrying the HLA-B 1502 with AEDs-induced SJS was 6.25（95% CI： 1.06–36.74） and 4.86（95% CI： 1.01–23.47）. The sensitivity and specificity of HLA-B 1502 for prediction of AEDs-induced SJS were 71.4%. The sensitivity and specificity of HLA-B 1502 for prediction of CBZ-induced SJS were 60% and 94%. HLA-B 1502 was not found in 11 children with maculopapular exanthema（MPE）（n=9） and hypersensitivity syndrome（HSS）（n=2）. However, we also found one case of CBZ-induced SJS who was negative for HLA-B 1502 but carried HLA-B 1511. It was suggested that the association between the CBZ-induced SJS and HLA-B 1502 allele in Han Chinese children can extend to other aromatic AEDs including OXC and PB related SJS. HLA-B 1511 may be a risk factor for some patients with CBZ-induced SJS negative for HLA-B 1502. |
| 关 键 词： | HLA-B 药物耐受性 中国汉族 抗癫痫 等位基因 综合征 约翰逊 特异性引物 |
Association of HLA-B*1502 and *1511 allele with antiepileptic drug-induced Stevens-Johnson syndrome in central China |
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| Dan Sun,Chun-hua Yu,Zhi-sheng Liu,Xue-lian He,Jia-sheng Hu,Ge-fei Wu,Bing Mao,Shu-hua Wu,Hui-hui Xiang. Association of HLA-B*1502 and *1511 allele with antiepileptic drug-induced Stevens-Johnson syndrome in central China[J]. Journal of Huazhong University of Science and Technology. Medical sciences, 2014, 34(1): 146-150. DOI: 10.1007/s11596-014-1247-7 | |
| Authors: | Dan Sun Chun-hua Yu Zhi-sheng Liu Xue-lian He Jia-sheng Hu Ge-fei Wu Bing Mao Shu-hua Wu Hui-hui Xiang |
| Affiliation: | 1. Department of Pediatric Neurology, Wuhan Children’s Hospital, Wuhan, 430016, China 2. Department of Science Research and Education, Wuhan Children’s Hospital, Wuhan, 430016, China 3. Department of Central Laboratory, Wuhan Children’s Hospital, Wuhan, 430016, China |
| Abstract: | Stevens-Johnson syndrome antiepileptic drugs children HLA-B 1511 HLA-B 1502 |
| Keywords: | Stevens-Johnson syndrome antiepileptic drugs children HLA-B 1511 HLA-B 1502 |
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