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Clinical Characteristics of Hereditary Multiple Exostoses: A Retrospective Study of Mainland Chinese Cases in Recent 23 Years
引用本文:郭雪玲,邓燕,刘辉国. Clinical Characteristics of Hereditary Multiple Exostoses: A Retrospective Study of Mainland Chinese Cases in Recent 23 Years[J]. 华中科技大学学报(医学英德文版), 2014, 34(1): 42-50. DOI: 10.1007/s11596-014-1230-3
作者姓名:郭雪玲  邓燕  刘辉国
基金项目:supported by the National Natural Science Foundation of China(No.81070067)
摘    要:
Hereditary multiple exostoses(HME) are an autosomal dominant skeletal disease with wide variations in clinical manifestations among different ethnic groups. This study investigated the epidemiology, clinical presentations, pathogenetic features and treatment strategies of HME in mainland China. We searched and reviewed the related cases published since 1990 by searching electronic databases, namely SinoMed database, Wanfang database, CNKI, Web of Science and PubMed as well as Google search engines. A total of 1051 cases of HME(male-to-female ratio 1.5:1) were investigated and the diagnosis was made in 83% before the age of 10 years. Approximately 96% patients had a family history. Long bones, ribs, scapula and pelvis were the frequently affected sites. Most patients were asymptomatic with multiple palpable masses. Common complications included angular deformities, impingement on neighbouring tissues and impaired articular function. Chondrosarcomas transformation occurred in 2% Chinese cases. Among the cases examined, about 18% had mutations in EXT1 and 28% in EXT2. Frameshift, nonsense and missense mutations represented the majority of HME-causing mutations. Diagnosis of HME was made based on the clinical presentations and radiological documentations. Most patients needed no treatment. Surgical treatment was often directed to remove symptomatic exostoses, particularly those of suspected malignancy degeneration, and correction of skeletal deformities. This study shows some variance from current literature regarding other ethnic populations and may provide valuable baseline assessment of the natural history of HME in mainland China.

关 键 词:中国内地  多发性  遗传性  临床特征  案件  万方数据库  临床表现  手术治疗

Clinical characteristics of hereditary multiple exostoses: A retrospective study of mainland chinese cases in recent 23 years
Xue-ling Guo,Yan Deng,Hui-guo Liu. Clinical characteristics of hereditary multiple exostoses: A retrospective study of mainland chinese cases in recent 23 years[J]. J. Huazhong Univ. Sci. Technol. Med. Sci., 2014, 34(1): 42-50. DOI: 10.1007/s11596-014-1230-3
Authors:Xue-ling Guo  Yan Deng  Hui-guo Liu
Affiliation:1. Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Key Laboratory of Respiratory Disease of the Ministry of Health, Wuhan, 430030, China
Abstract:
EXT1 EXT2 epidemiology hereditary multiple exostoses osteochondromas
Keywords:EXT1  EXT2  epidemiology  hereditary multiple exostoses  osteochondromas
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