| 维持性血液透析患者血清铁调素水平与心血管疾病的关系 |
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| 引用本文： | 徐雁,王玉红,林善丽,衣少娜,葛俊,贺延波.维持性血液透析患者血清铁调素水平与心血管疾病的关系[J].同济大学学报(医学版),2016,37(2):82-86. |
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| 作者姓名： | 徐雁 王玉红 林善丽 衣少娜 葛俊 贺延波 |
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| 作者单位： | 滨州医学院烟台附属医院肾内科,山东 烟台 264100,滨州医学院烟台附属医院肾内科,山东 烟台 264100,滨州医学院烟台附属医院肾内科,山东 烟台 264100,滨州医学院烟台附属医院肾内科,山东 烟台 264100,滨州医学院烟台附属医院肾内科,山东 烟台 264100,滨州医学院烟台附属医院肾内科,山东 烟台 264100 |
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| 摘 要： | 目的 探讨血清铁调素与维持性血液透析(maintenance hemodialysis, MHD)患者心血管疾病(cardiovascular disease, CVD)的关系。方法 稳定的MHD患者75例入选,年龄匹配的健康人20例为对照组。酶联免疫吸附法测定血清铁调素、晚期氧化蛋白产物(advanced oxidation protein products, AOPP)和IL-6。Spearman相关和线性回归分析铁调素与其他指标的相关性；二分类Logistic回归分析各指标与CVD的相关性。结果 MHD患者铁调素水平显著高于健康对照组249.2(169.0~475.2)ng/ml vs 84.7(49.6~179.3)ng/ml,P＜0.05]。CVD患者铁调素水平明显高于无CVD者335.9(206.3~514.2)ng/ml vs 210.5(133.6~392.3)ng/ml,P＜0.05]。Spearman相关分析显示铁调素与每周促红细胞生成素(EPO)剂量、EPO抵抗指数、铁蛋白、转铁蛋白饱和度、AOPP、高敏C反应蛋白、IL-6及左心室质量指数呈正相关,与血清前白蛋白、总铁结合力、不饱和铁结合力、转铁蛋白呈负相关。线性回归分析显示铁蛋白、总铁结合力、IL-6与铁调素水平独立相关。二分类Logistic回归分析显示铁调素升高为CVD发生的独立危险因素。结论 MHD患者血清铁调素水平与CVD相关,血清铁调素可能是MHD患者CVD新的标志物及治疗靶目标。
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| 关 键 词： | 铁调素 血液透析 心血管疾病 炎症 铁 |
| 收稿时间： | 2015/6/24 0:00:00 |
Relationship of serum hepcidin with cardiovascular disease in maintenance hemodialysis patients |
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| XU Yan,WANG Yu-hong,LIN Shan-li,YI Shao-n,GE Jun and HE Yan-bo.Relationship of serum hepcidin with cardiovascular disease in maintenance hemodialysis patients[J].Journal of Tongji University(Medical Science),2016,37(2):82-86. |
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| Authors: | XU Yan WANG Yu-hong LIN Shan-li YI Shao-n GE Jun and HE Yan-bo |
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| Institution: | Dept. of Nephrology, Yantai Hospital Affiliated to Binzhou Medical University, Yantai 264100, Shandong Province, China,Dept. of Nephrology, Yantai Hospital Affiliated to Binzhou Medical University, Yantai 264100, Shandong Province, China,Dept. of Nephrology, Yantai Hospital Affiliated to Binzhou Medical University, Yantai 264100, Shandong Province, China,Dept. of Nephrology, Yantai Hospital Affiliated to Binzhou Medical University, Yantai 264100, Shandong Province, China,Dept. of Nephrology, Yantai Hospital Affiliated to Binzhou Medical University, Yantai 264100, Shandong Province, China and Dept. of Nephrology, Yantai Hospital Affiliated to Binzhou Medical University, Yantai 264100, Shandong Province, China |
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