A soluble antigen of the mammary tumor virus |
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| Authors: | R C Nowinski L J Old D H Moore G Geering E A Boyse |
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| Affiliation: | 1. Centre Léon Bérard, Department of biopathology, 28 rue Laënnec, 69373 Lyon, France;2. University of Grenoble Alpes, F-38000, Grenoble, France;3. CHU Grenoble-Alpes, Department of radiology, 38043 Grenoble, France;4. CHU Grenoble-Alpes, Department of pathology, 38043 Grenoble, France;5. Institute for Advanced Biosciences, CNRS UMR5309, Inserm U1209, Grenoble Alpes, University F-38000, Grenoble, France;6. Cancer Research Center of Lyon, Equipe Labellisée Ligue contre le Cancer, Université de Lyon, Université Claude Bernard Lyon 1, INSERM 1052, CNRS 5286, Lyon, France;1. GNSS Research Center, Wuhan University, Wuhan 430079, China;2. Artificial Intelligence Institute, Wuhan University, Wuhan 430072, China;3. Dolby Laboratories, Sydney, NSW 2060, Australia;4. Australian Centre for Space Engineering Research, University of New South Wales, Sydney, NSW 2052, Australia |
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| Abstract: | A soluble antigen (MTV-s1), a subunit of the mammary tumor virus (MTV), is demonstrable by immunoprecipitation with rabbit antiserum prepared against MTV from infective milk of RIII mice. MTV-s1 antigen occurs in mammary tumors of MTV+ mice, milk of MTV+ mice and in ML+ leukemias. MTV-s1 antigen is released from intact MTV by treatment with ether. Sera prepared in mice against mammary tumors or against ML+ leukemias have precipitating antibody for MTV-s1, showing that the mouse is capable of an immune response to MTV. The demonstration of MTV-s1 in tumor extracts or in the milk of individual mice in immunoprecipitation provides the most rapid and direct method for detecting infection with MTV. |
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