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结核分枝杆菌利福平依赖株与耐药株的耐药状况比较
引用本文:杨彩娥,王琰,雷红,孙彬,孟祥红,董梅. 结核分枝杆菌利福平依赖株与耐药株的耐药状况比较[J]. 中国防痨杂志, 2011, 33(3): 163-165
作者姓名:杨彩娥  王琰  雷红  孙彬  孟祥红  董梅
作者单位:解放军第309医院检验科,北京,100091
摘    要:目的 调查结核分枝杆菌利福平依赖株和耐药株对临床常用抗结核药物的耐药性差异,并探讨其临床意义。 方法 采用匡氏双相琼脂培养基分离痰结核分枝杆菌并作耐药性和依赖性测定。 结果依赖组菌株对8种药物的耐药率均高于耐药组菌株,2组菌株对链霉素(S)、乙胺丁醇(E)、对氨基水杨酸 (PAS)、阿米卡星(Am)的耐药率差异有统计学意义(P<0.05),对左氧氟沙星(Lfx)的耐药率差异有统计学意义(P<0.01);100%依赖株和98.6%耐药株为MDR株;依赖株和耐药株中XDR菌株的比例分别为14.6%和5.8%,P=0.05。 结论 结核分枝杆菌利福平依赖株均为MDR株,对一线和二线抗结核药物耐药率高,XDR株比例高,应予高度警惕和关注。

关 键 词:分枝杆菌  结核  利福平  微生物敏感性试验  
收稿时间:2010-09-03

Comparative analysis on the anti-tuberculosis drug resistance of the rifampin-dependent and-resistant strains of Mycobacterium tuberculosis
Yang Caie,Wang Yan,Lei Hong,Sun Bin,Meng Xianghong,Dong Mei. Comparative analysis on the anti-tuberculosis drug resistance of the rifampin-dependent and-resistant strains of Mycobacterium tuberculosis[J]. The Journal of The Chinese Antituberculosis Association, 2011, 33(3): 163-165
Authors:Yang Caie  Wang Yan  Lei Hong  Sun Bin  Meng Xianghong  Dong Mei
Affiliation:Department of Clinical Laboratory, 309th Hospital of PLA, Beijing 100091, China
Abstract:Objective To compare the drug resistance patterns of rifampin(R)-dependent Mycobacterium tuberculosis with R-resistant Mycobacterium tuberculosis.Methods The double-phase Kuang's agar medium was used to culture and isolate M.tuberculosis from the patient's sputum specimens.Patterns of drug resistance and rifampin-dependence were determined simultaneously.Results The R-dependent M.tuberculosis strains exhibited higher rates of resistance to all the 8 anti-tuberculosis drugs than the R-resistant strains.The rates of resistance to streptomycin,ethambutol,paraminosalicylic acid and amikacin in these two groups of strains showed significant difference(P0.05),and the resistance to levofloxacin had highly significant difference(P0.01).100% of R-dependent strains and 98.6% of R-resistant strains showed the resistance to multi-drugs.The ratio of extensively drug-resistant(XDR) isolates in the R-dependent strains and R-resistant strains were 14.6% and 5.8%(P=0.05),respectively.Conclusion All the rifampin-dependent Mycobacterium tuberculosis strains were multi-drug resistant(MDR),which showed high drug resistance rate against first-line and second-line drugs and had more XDR strains.
Keywords:Mycobacterium tuberculosis  rifampicin  microbial sensitivity test
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