探讨表皮生长因子和瘦素检测在胃癌诊断中的临床意义

目的探讨胃癌患者外周血表皮生长因子（epidermal growth factor，EGF）和瘦素水平的变化及与肿瘤发生发展过程和预后判断的关系。方法收集2013年1月至2013年8月来我院就诊并确诊的胃癌患者150例，及同期健康体检者50例。采用放射免疫分析法检测所有受试者的血清EGF、瘦素和甲胎蛋白（alphafetoprotein，AFP）水平，并对所得数据进行统计分析。结果胃癌患者血清EGF、瘦素和AFP水平均显著高于对照组，差异均有统计学意义（P均〈0．05）。直线相关分析显示，胃癌患者的EGF与AFP水平呈正相关（r=0．291，P〈0．05），其余检测指标间无相关性。结论胃癌患者血清中存在高水平的EGF和瘦素，两者之间相互独立发挥作用，血清EGF水平有助于胃癌诊断和预后评估。

Discussion clinical significance of epidermal growth factor and leptin detection in gastric carcinoma diagnosis

Objective To explore the relationship between epidermal growth factor（EGF） and leptin levels change with gastric carcinoma development. Methods 150 cases gastric carcinoma patients （gastric carcinoma group） and 50 cases healthy people（control group） were collected in our hospital from January 2013 to Autumn 2013. levels of EGF, leptin and alphafetoprotein （AFP） were detected by radio immunoassay. All data were analyzed statistically. Results The levels of EGF, leptin and AFP in gastric carcinoma group were all higher than that of control group, and the differences all had statistical significance （Pall〈 0.05）. Linear correlation analysis showed that level of EGF in gastric carcinoma patient had positive correlation with level of AFP （r= 0.291, P〈 0.05）, and the other index had no relationship. Conclusion Gastric carcinoma patients have high levels of EGF and leptin, but these two index are independent of each other. Level of EGF have con- tribution to diagnosis and prognosis evaluation of gastric carcinoma.