| 46例骨髓增生异常综合征临床分析以及意义 |
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| 引用本文： | 朱凤娇,顾保罗,杨群政,童向民. 46例骨髓增生异常综合征临床分析以及意义[J]. 中国卫生检验杂志, 2012, 0(5): 1078-1080 |
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| 作者姓名： | 朱凤娇 顾保罗 杨群政 童向民 |
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| 作者单位： | 浙江省三门县人民医院检验科;浙江省杭州市萧山区第一人民医院;浙江省富阳市中医院;浙江大学医学院附属第一医院 |
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| 基金项目： | 浙江省卫生厅(2011ZDA008);杭州市科技局项目(20110833B53,20110833B42)资助 |
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| 摘 要： | 目的:研究骨髓增生异常综合征患者病态造血、外周血象与恶性克隆负荷的相关性。方法:回顾分析46例MDS患者,研究MDS骨髓病态造血、外周血象与恶性克隆负荷的相关性。结果:可见双核粒细胞、奇数核红细胞、粒细胞分叶不良与MDS高恶性克隆负荷显著相关(P<0.05);骨髓三系病态造血具有显著较高的克隆负荷(P<0.05);外周血出现幼稚粒细胞是高克隆负荷的指征(P<0.05)。结论:MDS高恶性克隆负荷的指标包括:双核粒细胞、奇数核红细胞、粒细胞分叶不良、三系病态造血、外周血出现幼稚粒细胞。
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| 关 键 词： | 骨髓增生异常综合征 恶性克隆负荷 病态造血 |
Clinical analysis of forty-six patients with myelodysplastic syndrome |
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| ZHU Feng-jiao,GU Bao-luo,YANG Qun-zheng,TONG Xiang-min. Clinical analysis of forty-six patients with myelodysplastic syndrome[J]. Chinses Journal of Health Laboratory Technology, 2012, 0(5): 1078-1080 |
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| Authors: | ZHU Feng-jiao GU Bao-luo YANG Qun-zheng TONG Xiang-min |
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| Affiliation: | 1.The People′s Hospital of Zhejiang Sanmen,Taizhou 317100,PR.China;2.The First People′s Hospital of Hangzhou Xiaoshan,Hangzhou 311200,PR.China;3.The TCM Hospital of Hangzhou Fuyang,Hangzhou 311400,PR.China;4.The First Affiliated Hospital of College of Medicine,Zhejiang University,Hangzhou 310003,China) |
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| Abstract: | Objective:To investigate the correlation of dysplasia,peripheral blood and malignant clone load in patients with myelodysplastic syndrome.Methods: 46 MDS patients were selected for retrospective analysis.Results: Binucleated granulocyte,odd nucleated erythrocytes and granulocytes leaf dysplasia had significant correlation with high malignant clone load in MDS(P<0.05).RCMD was found have higher clone load(P<0.05).Immature granulocytes in peripheral blood was an indication of high clone load(P<0.05).Conclusion: MDS high malignant clone load indicators included binucleated granulocyte,odd nucleated erythrocytes,granulocytes leaf dysplasia,RCMD and immature granulocytes in peripheral blood. |
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| Keywords: | Myelodysplastic syndrome Malignant clone load Dysplasia |
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