| 肠黏膜屏障和益生菌的研究进展 |
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| 引用本文： | 谢一潋,李兰娟. 肠黏膜屏障和益生菌的研究进展[J]. 国际流行病学传染病学杂志, 2009, 36(2). DOI: 10.3760/cma.j.issn.1673-4149.2009.02.016 |
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| 作者姓名： | 谢一潋 李兰娟 |
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| 作者单位： | 浙江大学医学院附属第一医院传染病诊治国家重点实验室,杭州,310003;浙江大学医学院附属第一医院传染病诊治国家重点实验室,杭州,310003 |
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| 摘 要： | 肠道内存在大最的共生菌,共生菌与肠上皮组织之间通过一定的相互作用机制而保持稳定的耐受状态,当肠道菌群紊乱时会打破这一平衡,通过Toll样受体(TLR)或核苷酸结合寡聚化结构域(NOD)识别激活NF-кB,促进炎症基因的转录,大量炎症介质释放,引起肠黏膜损伤.近年从分子基因水平上发现益生菌能通过抑制NF-кB而减轻炎症反应,起抗炎作用的可以是活菌,也可以是灭活菌或DNA.
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| 关 键 词： | 肠黏膜 屏障 益生菌 |
Research progress on intestinal mucosal barrier and probiotics |
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| XIE Yi-lian,LI Lan-juan. Research progress on intestinal mucosal barrier and probiotics[J]. International Journal of Epidemiology and Infectious Disease, 2009, 36(2). DOI: 10.3760/cma.j.issn.1673-4149.2009.02.016 |
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| Authors: | XIE Yi-lian LI Lan-juan |
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| Abstract: | The intestine contains numerous commensal bacteria. The commensal bacterial and intestinal epithelium interact with each other through a certain mechanism, restdting in a situation of tolerance, which can be broken up by the disturbance of the intestinal flora. The bacteria can be recognized by TLR(Toll-like receptor) or NOD( nucleotide-binding a large number of inflammatory mediators are released to cause the damage of the intestinal mucosa. In recent years, it The inactivated probiotic or its DNA may have the same function with the live one. |
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| Keywords: | Intestinal mucosal Barrier Probiotics |
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