脑卒中后抑郁症患者血浆皮质醇的含量变化及临床意义

目的探讨脑卒中后抑郁症患者血浆皮质醇的含量变化及临床意义。方法选择本院2010年9月-2011年8月收治的脑卒中患者59例作为观察组,采用汉密顿抑郁量表(HAMD)测定后分为抑郁组21例和非抑郁组38例,均测定血浆皮质醇的含量变化,以在本院检测血浆皮质醇含量正常的32例作为对照组,分析脑卒中后抑郁症患者血浆皮质醇的含量变化特点。结果观察组患者清晨8时、下午4时、夜间12时的血浆皮质醇浓度均明显高于对照组,组间差异有统计学意义(P<0.05);抑郁组脑卒中患者清晨8时、下午4时、夜间12时的血浆皮质醇浓度均明显高于非抑郁组,组间差异有统计学意义(P<0.05)。结论脑卒中后抑郁症患者血浆皮质醇的含量变化更为明显,应引起临床工作者的注意,积极采取相应的治疗措施。

Concentration Change and Clinical Significance of Plasma Cortisol in Patients with Post - stroke Depression

Objective To explore the concentration variation and clinical value of plasma cortisol in patients with post-stroke depression. Methods Fifty-nine patients with post-stroke depression admitted to Cerebrovascular Disease Hospital of Baoding from September 2010 to August 2011 were selected as observation group.According to the scores of Hamilton rating scale for depression（HAMD）,they were divided into depression group（n=21） and non-depression group（n=38）,and the concentration change of plasma cortisol of all the patients was determined.32 cases with normal plasma cortisol levels detected in our hospital were served as control group.The features of concentration change of plasma cortisol of patients with post-stroke depression were analyzed. Results The plasma cortisol concentrations at 8：00 am,16：00 and 0：00 pm in patients of observation group were significantly higher than those of control group,and the difference was statistically significant between the two groups（P0.05）.The plasma cortisol concentrations at 8：00 am,16：00 and 0：00 pm in patients of depression group were significantly higher than those of non-depression group,and the difference was statistically significant between the two groups（P0.05）. Conclusions The concentration change of plasma cortisol of patients with post-stroke depression is more significantly,which should be taken seriously by clinicians.And the corresponding therapeutic measures should be adopted actively.