Calcium–phosphorus homeostasis in cats with spontaneous chronic kidney disease and metabolic acidosis

The effect of metabolic acidosis on calcium–phosphorus homeostasis in cats with spontaneous chronic kidney disease (CKD) was studied. The cats were assigned into the clinically normal cats (n?=?6), CKD (n?=?9), and CKD with metabolic acidosis (12 cats). The CKD cats were cats with a blood urea nitrogen ≥50?mg/dl and creatinine level ≥2.1?mg/dl. A complete blood count, sodium, potassium, total calcium, adjusted calcium, ionized calcium, phosphorus, parathyroid hormone, and vitamin D levels were measured. The cats with spontaneous CKD had a significantly lower hemoglobin and pack cell volume than the clinically normal cats. The CKD cats with metabolic acidosis had mean creatinine levels of 7.12?±?0.76?mg/dl (severe azotemic stage) and significantly increased levels of parathyroid hormone and plasma phosphorus levels which indicated the presence of renal secondary hyperparathyroidism.