DLF方案加羟基喜树碱治疗晚期食管癌的临床观察

目的：寻找晚期食管癌的有效治疗方法。方法：自１９９５年３月至１９９８年４月以ＤＬＦ方案（顺铂、醛氢对酸,５－氯脲嘧啶）加与不加羟基喜树碱（ＨＣＰＴ）治疗晚期食管癌。结果：治疗组有效率６８．７％,而对照组为４３．３％,差异显著（Ｐ〈０．０５）。主要毒副作用为纳差、恶心或呕吐,其发生率为８５．３％,但多为１～２级;白细胞下降在治疗级和对照组分别为８２．４％和６３．４％。差异不具有统计学意义（Ｐ〉０．５

Clinical Observation on Esophageal Cancer Patients Treated with DLF Scheme Plus Hydrocamptothecin

Objective: To search an effective management for esophageal cancer patients. Methods: From March 1995 to April 1998, sixty-four cases of esophageal cancer were randomly divided into two groups: the treatment group recieved a combined therapy of cisplatin, leucovorin, 5-fluorouracil plus hydrocamptothecin (DLFH) and the control group recieved cisplatin,leucovorin and 5-fluorouracil (DLF) without hydrocamptothecin. The efficacy and toxicity in these two groups were evaluated after two courses of treatment. Results: The overall response rate of the treatment group was 68.7% , while the control group was 43.3% with significant difference ( P <0.05). The major toxicities included anorexia, nausea, vomiting, leucopenia and reduced platelete count, but it was tolerable in most of the patients. Conclusion: The combination regimen of DLFH is effective and safe for esophageal cancer patients.