胰岛素抵抗对血糖异常人群膳食干预效果的影响

目的 探讨胰岛素抵抗对血糖异常人群膳食十预效果的影响。方法从高脂血症人群社区综合干预项目中筛出血糖异常者194例作为研究对象，分为干预组（111例）和对照组（83例）。测定空腹血糖（FBG）和空腹胰岛素（FINS），计算胰岛素抵抗（IR）指数和胰岛素敏感性指数（IAI）值，分析IR和IAI与血糖、血脂及体检指标变化的关系。结果FBG、甘油三酯（TG）、腰围、腰臀比最低组与最高组之间，IR、IAI值差别有统计学意义。干预组中，胰岛素敏感性高的组干预后FBG、TG降低较明显。结论血糖、血脂、腰围及腰臀比与IR之间存在相关性，体重和体质指数与IR的相关性不显著。IR的程度与干预效果之间存在相关性。

Effect of Insulin Resistance on Dietary Interventions in People with Abnormal Blood Glucose

Objective To investigate the effect of insulin resistance(IR) on the persons with abnormal blood glucose who underwent dietary interventions.Methods 194 individuals with abnormal blood glucose were selected from hyperlipidemia population taking the community intervention program in districts of Beijing.The insulin resistance and insulin action index(IAI) were calculated with fasting blood glucose(FBG) and fasting blood insulin(FINS),and analyzed the relationship of variety on their blood glucose,serum lipids and body weight,body mass index(BMI),waist circumference,waist hip ratio(WHR).Results 1) Blood glucose(FBG),triglyceride(TG),waist circumference and WHR had significant positive relationship with IR but negative with IAI;2) In the intervention group,FBG and TG were reduced significantly in the subgroup with highest IAI.Conclusions IR was related with blood glucose,serum lipids,waist circumference and WHR,but no significant relation with body weight and BMI;It was possible that IR had some effect on dietary intervention.