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| 非粥样硬化性动脉狭窄模型的建立 | |
| 引用本文： | 唐承君,李永利,孟亮,董以谦,周燕文,杨舒娅,戴汝平,徐仲英,杜丽丽,宋来凤,王亚光. 非粥样硬化性动脉狭窄模型的建立[J]. 中国循环杂志, 1993, 0(12) |
| 作者姓名： | 唐承君 李永利 孟亮 董以谦 周燕文 杨舒娅 戴汝平 徐仲英 杜丽丽 宋来凤 王亚光 |
| 作者单位： | 中国医学科学院心血管病研究所阜外医院实验外科(唐承君，李永利，孟亮，董以谦，周燕文，杨舒娅)，中国医学科学院心血管病研究所阜外医院放射科(戴汝平，徐仲英，杜丽丽)，中国医学科学院心血管病研究所阜外医院病理科(宋来凤)，中国医学科学院心血管病研究所阜外医院病理科(王亚光) |
| 摘 要： | 本文报告用福尔马林溶液注射加医用肠线环扎建立犬髂总动脉狭窄模型的方法。30条存活3个月以上的犬,60支血管经造影证明有不同程度狭窄或完全阻塞者占91. 7%。组织学检查与非粥样硬化性大动脉炎的表现相似。该方法的建立为研究非粥样硬化性血管狭窄的介入治疗提供了较理想的实验动物模型。 |
| 关 键 词： | 非粥样硬化性 动脉狭窄模型 血管造影术 |
ANIMAL MODEL OF NONATHEROSCLEROTIC ARTERIAL STENOSIS |
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| Tang Cheng-Jun,Li Yong-Li,Meng Liang,et al.. ANIMAL MODEL OF NONATHEROSCLEROTIC ARTERIAL STENOSIS[J]. Chinese Circulation Journal, 1993, 0(12) | |
| Authors: | Tang Cheng-Jun Li Yong-Li Meng Liang et al. |
| Affiliation: | Tang Cheng-Jun,Li Yong-Li,Meng Liang,et al. Cardiovascular Institute and Fu Wai Hospital,CAMS,Beijing |
| Abstract: | An animal model of arterial sternosis was established successfully for 60 iliac arteries in 30 dogs. 10% formaldehyde was injected into the adventitial and medial layers of lilac artery which was then ligated with chromized catgut.Follow-up angiographic examination at 3th and 6th month showed mild stenosis in 11,moderate-severe stenosis in 24, complete occlusion in 20 and no significant change in 5 arteries. Histopathologic study, of the vessels showed characteristic changes of nonatherosclerotic arteritis.This study demonstrated that it is possible to establish animal model of non-atherosclerotic arterial lesion and to study the pathologic mechanism and efficacy of percutaneous transluminal angioplasty (PTA) for its treatment. |
| Keywords: | Arterial stenosis model Angiography Non-atherosclerotic |
| 本文献已被 CNKI 等数据库收录！ | |