| 甲氧基红霉素对卡马西平药物动力学的影响 |
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| 引用本文： | 谢守霞,董淳.甲氧基红霉素对卡马西平药物动力学的影响[J].中国临床药学杂志,1997,6(1):19-21. |
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| 作者姓名： | 谢守霞 董淳 |
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| 作者单位： | 深圳市人民医院药剂科临床药学室!深圳518020 |
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| 摘 要： | 应用荧光偏振免疫法，测定６只家兔ｐｏ卡马西平及连续多次ｐｏ用搓甲氧基红霉素后ｐｏ卡马西平的血清卡马西平浓度，用３ｐ８７程序包按二室模型对数据进行处理并进行统计学分析。
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| 关 键 词： | 甲氧基红霉素 卡马西平 药物动力学 |
THE EFFECT OF CLARITHROMYCIN ON PHARMACOKINETICS OF CARBAMAZEPINE IN RABBITS |
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| XIE Shou-Xia,DONG Chun,NING De-E.THE EFFECT OF CLARITHROMYCIN ON PHARMACOKINETICS OF CARBAMAZEPINE IN RABBITS[J].Chinese Journal of Clinical Pharmacy,1997,6(1):19-21. |
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| Authors: | XIE Shou-Xia DONG Chun NING De-E |
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| Abstract: | Serum concentration of carbamazepine was determined by fluorescence polarization immunoassay in 6 rabbits after administered carbamazepine alone and together with clarithromycin. The results indicated that clarithromycin dramatically increased mean Cmax, AUC by 38. 3% and 32. 6% respectively,and decreased mean serum carbamazepine clearance by 28. 5%(P<0. 05). We conclude that the combination of carbamazepine and clarithromycin represents a clinically significant drug interaction. We suggest that carbamazepine dosage should be reduced and take therapeutic drug monitoring. |
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| Keywords: | carbamazepine clarithromycin pharmacokinetics |
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