| 癫痫敏感大鼠内嗅皮层GABA及Kappa受体免疫反应活性的变化 |
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| 引用本文： | 程卫国,张剑平,王滨,赵杰,张万琴. 癫痫敏感大鼠内嗅皮层GABA及Kappa受体免疫反应活性的变化[J]. 中风与神经疾病杂志, 2005, 22(6): 513-514 |
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| 作者姓名： | 程卫国 张剑平 王滨 赵杰 张万琴 |
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| 作者单位： | 1. 江苏无锡第一人民医院神经内科,江苏,无锡,214001
2. 大连医科大学神经生理教研室,辽宁,大连,116023 |
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| 摘 要： | 目的研究癫痫敏感大鼠内嗅皮层(EC)GABA及Kappa受体免疫反应活性的变化。方法用惊厥剂量(10mg／kg．sc)的红藻氨酸(Kainic acid,KA)制备癫痫发作敏感大鼠,用免疫组化方法观察内嗅皮层(EC)GA- BA和Kappa受体免疫反应活性的变化。结果与对照组比较,KA后4周,癫痫敏感动物EC部位GABA免疫反应活性(GABA-IR)及Kappa受体免疫反应活性(Kappa-R-IR)均明显减少(P<0．05)。结论 EC处GABA-IR及Kap- pa-R-IR的长期下调很可能是大鼠癫痫发作敏感性长期增强的重要原因。
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| 关 键 词： | GABA Kappa受体 红藻氨酸 |
| 文章编号： | 1003-2754(2005)06-0513-02 |
| 收稿时间： | 2005-06-02 |
| 修稿时间： | 2005-10-24 |
The change of GABA and Kappa receptor immunoreactivity in entorhinal cortex of seizure sensitive rats |
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| CHENG Wei-guo, ZHANG Jian-ping , WANG Bin, et al. The change of GABA and Kappa receptor immunoreactivity in entorhinal cortex of seizure sensitive rats[J]. Journal of Apoplexy and Nervous Diseases, 2005, 22(6): 513-514 |
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| Authors: | CHENG Wei-guo ZHANG Jian-ping WANG Bin et al |
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| Affiliation: | Department of Neurology, The First Hospital of Wuxi , Wuxi 214001 ,China |
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| Abstract: | Objective To investigate the change of GABA and Kappa-Recepter immunoreactivity in entorhi-nal cortex (EC)of seizure sensitive rats. Methods Seizure sensitive rats were induced by convulsive dose(10mg/ kg)of Kainic acid(KA). The changes of GABA and Kappa-R in EC were observed in the seizure sensitive rats by immunohistochemistry technique. Result As compared with control rats,the number of GABA and Kappa-R positive neurons was markedly decreased (P<0. 01) in the EC of the seizure sensitive rats. Conclusion It revealed that the long-term downregulation of GABA and Kappa-R in EC was probably involved in long-term enhancement of seizure sensitivity in the chronic seizure rats. |
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| Keywords: | GABA Kappa-R Kainic Acid |
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