摩腹法对肠易激综合征白兔模型不同脑区激活特征的影响

目的]探讨摩腹法对便秘型肠易激综合征(IBS)白兔模型不同脑区激活的功能磁共振(fMRI)特征.方法]将新西兰白兔随机分为正常组、模型组和摩腹组,采用冰水灌胃与冰敷束缚相结合制备便秘型IBS动物模型.经摩腹干预,在第1次摩腹后即刻和第20次后两个时点观察3组动物功能磁共振脑区激活变化.结果]正常组白兔脑区激活部位在丘脑、扣带前回、脑岛皮质.模型组fMRI脑区激活部位在丘脑、扣带前回、脑岛皮质、脑干和小脑.其中在丘脑和扣带前回激活区域,模型组的激活象素和强度明显高于正常组(P<0.05).经摩腹第1次操作后,激活部位在丘脑、扣带前回、脑岛皮质、脑干;操作20次后,激活部位在丘脑、扣带前回、脑岛皮质,摩腹组激活脑区与模型组比较激活像素和激活强度显著降低(P<0.01).结论]摩腹法可以有效调控便秘型肠易激综合征家兔模型内脏敏感化中枢.

Influence of rubbing abdomen on regional encephalic activation in rabbits with irritable bowel syndrome

Objective] To investigate the fMRI characteristic and clinical effects of Rubbing abdomen on regional encephalic activation in rabbits with constipation-predominant irritable bowel syndrome(C-IBS). Methods] New Zealand male albino rabbits were randomly divided into normal group, model group and Rubbing abdomen group. C-IBS was induced in all rabbits by the combined ice water intragastric administration and ice compress constraint. Encephalic regions of fMRI were observed before and after the first massage...