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乌拉地尔配伍艾司洛尔在悬雍垂腭咽成形术中的应用
引用本文:岳红,郝建华. 乌拉地尔配伍艾司洛尔在悬雍垂腭咽成形术中的应用[J]. 新乡医学院学报, 2010, 27(5)
作者姓名:岳红  郝建华
作者单位:解放军总医院第一附属医院麻醉科
摘    要:
目的探讨乌拉地尔配伍艾司洛尔应用于悬雍垂腭咽成形术的可行性。方法美国麻醉医师协会分级Ⅰ~Ⅱ级阻塞性睡眠呼吸暂停低通气综合征患者80例,随机分为观察组和对照组各40例,2组采用相同的麻醉方法,观察组麻醉后静脉泵入乌拉地尔,根据心率(HR)和平均动脉压(MAP)间断10min静脉注射艾司洛尔,并记录麻醉前、手术开始后1、2h、手术结束后15min2组的HR和MAP,记录术野显露清晰满意度、手术时间、出血量、输液量、苏醒及拔管时间。结果观察组与对照组麻醉前HR和MAP比较差别无统计学意义(P>0.05)。对照组手术1、2h、手术结束15min的HR和MAP与术前比较差别均无统计学意义(P>0.05);观察组手术1、2h、手术结束15min的HR和MAP较术前明显降低(P<0.05),且与对照组同时间点比较明显降低,差别有统计学意义(P<0.05)。观察组术野显露清晰满意度明显优于对照组(P<0.05);观察组手术时间、出血量、输注液体总量、苏醒及拔管时间均少于对照组(P<0.05)。结论乌拉地尔配伍艾司洛尔能有效减少手术出血量,改善术野显露清晰度,使围手术期血压和HR更为平稳。

关 键 词:乌拉地尔 艾司洛尔 悬雍垂 腭 咽

Application of urapidil combine with esmolol in uvulopalatopharyngoplasty
YUE Hong,HAO Jian-hua. Application of urapidil combine with esmolol in uvulopalatopharyngoplasty[J]. Journal of Xinxiang Medical College, 2010, 27(5)
Authors:YUE Hong  HAO Jian-hua
Affiliation:Department of Anesthesiology; the First Affiliated Hospital of Chinese PLA General Hospital; Beijing 100086; China
Abstract:
Objective To explore the feasibility of urapidil combine with esmolol used in uvulopalatopharyngoplasty( UPPP) . Methods Eighty American Society of Anesthesiologists Ⅰ Ⅱ patients who suffered from obstructive sleep apnea-hypopnea syndrome were randomly divided into control group and observation group,forty patients in each group. The anesthesia method in the two groups was identical,but postanesthetic the observation group was infused with urapidil. Esmolol was infused every ten minutes according to the heart rate and mean artery pressure. Heart rate and mean artery pressure were recorded before induced,1 hour and 2 hours afteroperation,15 minutes postoperation. Operative view clarity,operative time,blood loss,infusive volume,wake and extubation time were observed. Results There was no statistically significant between the two groups in heart rate and mean artery pressure preanesthesia( P > 0. 05) . There was no statistically significant at 1 hour,2 hours afteroperation and after 15 minutes at the end of operation compared with preoperative heart rate and mean artery pressure in the control group( P > 0. 05) . But those of the observation,group decreased significantly( P < 0. 05) . At the same time the heart rate and mean artery pressure decreased significantly in observation,group compared with control group( P < 0. 05) . Operative view clarity was better in observation,group than control group( P < 0. 05) ; Operative time,blood loss,infusive volume,wake and extubation time were less in observation,group than those in control group( P < 0. 05) . Conclusion Urapidil combine with esmolol can effectively decrease blood loss and improve operative view clarity,and take blood pressure and heart rate to be more stable.
Keywords:urapidil   esmolol   uvula   palate   pharynx
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