Effect of ampicillin on mefloquine pharmacokinetics in thai males |
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Authors: | J. Karbwang K. Na Bangchang D. J. Back D. Bunnag |
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Affiliation: | (1) Department of Clinical Tropical Medicine and Hospital for Tropical Diseases, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand;(2) Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool, England |
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Abstract: | ![]() Summary The kinetics of a single oral dose of mefloquine given either alone or with ampicillin has been studied in 8 healthy Thai male volunteers.There was a significantly higher maximum whole blood mefloquine concentration after coadministration with ampicillin (1648 vs 1228 ng·ml–1), as well as a significantly reduced terminal half life (15.3 vs 17.7 days), mean residence time (20.1 vs 23.4 days) and volume of distribution at steady state (14.1 vs 19.4 l·kg–1). Although there was no significant change in the AUC from zero time to infinity, the AUC from zero time to 5 days was significantly increased by ampicillin (4.86 vs 3.27 g·ml–1 day).These changes in mefloquine disposition after antibiotic treatment may be due both to an increase in fractional bioavailability and a reduction in the enterohepatic recycling of mefloquine. |
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Keywords: | Mefloquine ampicillin Thai subjects pharmacokinetics enterohepatic recycling drug interaction adverse effects |
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