红花化学成分 药理作用研究进展及质量标志物预测分析

红花为常用活血化瘀药,临床主要用于治疗高血压、冠心病、脑血栓等心脑血管疾病。红花含有黄酮、生物碱、聚炔、亚精胺、甾醇、木脂素、多糖等类化学成分,具有抗心肌缺血、调节血流动力学、抗炎、镇痛、抗氧化、调节免疫力等药理作用。对红花主要化学成分及其药理作用研究进展进行综述,在此基础上,结合质量标志物的研究思路,从化学成分、临床药效、药动学及网络药理学等方面进行红花质量标志物预测分析,为其质量综合评价及临床应用研究提供参考。

Research Progress on Chemical Constituents and Pharmacological Effects of Carthamus tinctorius and Predictive Analysis on Quality Markers

Carthamus tinctorius is a commonly used medicine for promoting blood circulation and removing blood stasis. It is mainly used for the clinical treatment of cardiovascular and cerebrovascular diseases such as hypertension, coronary heart disease and cerebral thrombosis. In this paper, the main chemical composition of C. tinctorius such as flavonoids, alkaloids, polyalkynes, spermidines, sterols, lignans, polysaccharides and its pharmacological effects such as anti-myocardial ischemia, regulating hemodynamics, anti-inflammatory,anti-oxidation, regulating immunity were summarized. On this basis, combining with the concept of quality markers, the quality markers of safflower were predicted and analyzed from the aspects of chemical composition, clinical efficacy, pharmacokinetics and network pharmacology, which can establish scientific quality standards of C. tinctorius.