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| 内皮素受体拮抗剂在重症急性胰腺炎大鼠心肌损伤中的保护作用 | |
| 引用本文： | 戎祯祥,JU Yong-le,陈小伍,WU Jin-hao,朱达坚,林雍熙.内皮素受体拮抗剂在重症急性胰腺炎大鼠心肌损伤中的保护作用[J].中华普通外科学文献（电子版）,2008,2(3):10-12. |
| 作者姓名： | 戎祯祥 JU Yong-le 陈小伍 WU Jin-hao 朱达坚 林雍熙 |
| 作者单位： | 1. 广东省佛山市顺德区第一人民医院胃肠胰疝外科,佛山,528300 2. Department of Gastroenterologic, Pancreatic and Hernia Surgery, the First Hospital of Shun De of Southern Medical University, Fo Shan 528300, China 3. 广东省佛山市顺德区第一人民医院肝胆脾甲状腺外科,佛山,528300 |
| 基金项目： | 广东省医学科研基金项目(WSTJJ20031116) |
| 摘 要： | 目的探讨内皮素受体拮抗剂（ET—RA）对重症急性胰腺炎（SAP）大鼠心肌损伤的治疗作用。方法将30只SD大鼠随机分成3组：重症急性胰腺炎组（SAPG）：胰管逆行注射5％牛黄胆酸钠的方法建立大鼠SAP模型；正常对照（CG）组：处理方法同上，改推注同体积的生理盐水；ET-1受体拮抗剂治疗组（ET—RAG）：SAP成模后6h腹腔内注射ET—RA，对照组与SAPG注射等体积生理盐水。观察24h后取标本，分别测定各组血浆淀粉酶（AML）、激酸激酶（CK）及其同工酶（CK—MB）、乳酸脱氢酶-1（LDHl）、ET-1、TNF-α的变化。结果AML、CK—MB、CK、LDH-1、ET-1、TNF-α在SAPG及ET—RAG均显著高于正常对照组（P〈0．01），而ET—RAG中以上指标的浓度亦显著低于SAPG（P〈0．05）。结论ET—RA对SAP时的心肌损伤有较好的治疗作用。 |
| 关 键 词： | 内皮素受体拮抗剂 重症急性胰腺炎 心肌酶 TNF-α |
Protective effect of endothelin receptor antagonist on heart injury in severe acute pancreatitis rats |
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| RONG Zhen-xiang,JU Yong-le,CHEN Xiao-wu,WU Jin-hao,ZHU Da-jian,LIN Yong-xi.Protective effect of endothelin receptor antagonist on heart injury in severe acute pancreatitis rats[J].Chinese Journal of General Surgery(Electronic Version),2008,2(3):10-12. | |
| Authors: | RONG Zhen-xiang JU Yong-le CHEN Xiao-wu WU Jin-hao ZHU Da-jian LIN Yong-xi |
| Institution: | RONG Zhen-xiang, JU Yong-le, CHEN Xiao-wu, WU Jin-hao, ZHU Da-jian, LIN Yong-xi. (Department of Gastroenterologic, Pancreatic and Hernia Surgery, the First Hospital of Shun De of Southern Medical University, Fo Shah 528300, China) |
| Abstract: | Objective To explore the effect of treatment of endothelin receptor antagonist (ET-RA) on heart injury in severe acute pancreatitis (SAP) rats. Methods Thirty SD rats were randomly allocated into 3 groups: SAP group(SAPG): Main pancreatic duct was perfused with Sodium Cholate (5%) to induce SAP; Control group(CG): To do the same as that of SAP group, except with normal saline; ET-RA group(ET-RAG): Rats were treated with intraperitoneal injection of ET-RA after the models of SAP were done for 6 hours, while ... |
| Keywords: | ET-RA Severe acute pancreatitis Myocardial enzyme TNF-α |
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