拉莫三嗪辅助治疗前庭性偏头痛的临床效果及对血清神经递质水平的影响

目的 探讨拉莫三嗪辅助治疗前庭性偏头痛的临床效果及对血清神经递质水平的影响。方法 选择本院2018年4月-2019年7月接诊的前庭性偏头痛患者85例,通过随机数表法分为观察组45例和对照组40例,对照组给予盐酸氟桂利嗪胶囊治疗,观察组给予盐酸氟桂利嗪胶囊联合拉莫三嗪治疗,均连续治疗2个月,并比较2组临床疗效、眩晕情况、血清神经递质水平的变化及不良反应。结果 治疗2个月后观察组总有效率明显高于对照组(91.11% vs 72.50%)(P<0.05); 观察组眩晕发作次数、每次眩晕严重程度均明显低于对照组,眩晕持续时间明显短于对照组[(2.05±0.47)vs(2.94±0.61)次/月,(2.43±0.63)vs(3.59±0.88)分,(8.76±1.74)vs(10.09±2.11)h](P<0.05); 观察组血清降钙素基因相关肽(CGRP)、P物质(SP)、内皮素-1(ET-1)水平明显低于对照组[(56.75±8.01)vs(66.42±9.65)ng/L,(162.30±15.42)vs(184.21±17.27)ng/L,(72.30±11.38)vs(88.27±13.47)pg/mL](P<0.05); 2组不良反应总发生率无明显差异[13.33% vs 12.50%](P>0.05)。结论 在氟桂利嗪基础上联合拉莫三嗪辅助治疗前庭性偏头痛的疗效显著,可有效改善血清神经递质表达水平,缓解临床症状,安全性好

Clinical effect of lamotrigine in the adjuvant treatment of vestibular migraine and its effect on serum neurotransmitter levels

ObjectiveTo study the clinical effect of lamotrigine in the adjuvant treatment of vestibular migraine and its effect on serum neurotransmitter levels.Methods 85 patients of vestibular migraine who received therapy from April 2018 to December 2019 in our hospital were selected, according to the random number table, those patients were divided into 45 cases in the observation group and 40 cases in the control group, the control group was treated with Flunarizine Hydrochloride Capsules, while the observation group was combined with lamotrigine, they were treated continuously for two months. The clinical efficacy, vertigo, changes of serum neurotransmitter levels and adverse reactions were compared between the two groups.Results After treatment, the total effective rate in the observation group was higher than that in the control group [91.11% vs 72.50%](P<0.05). The number of vertigo attacks and the severity of vertigo in the observation group were lower than those in the control group, and the duration of vertigo was significantly shorter than that in the control group [(2.05±0.47)vs(2.94±0.61)time/months,(2.43±0.63)vs(3.59±0.88)scores,(8.76±1.74)vs(10.09±2.11)h](P<0.05). The serum levels of calcitonin gene-related peptide(CGRP), substance P(SP), endothelin-1(ET-1)in the observation group were lower than those in the control group [(56.75±8.01)vs(66.42±9.65)ng/L,(162.30±15.42)vs(184.21±17.27)ng/L,(72.30±11.38)vs(88.27±13.47)pg/mL](P<0.05). There was no significant difference in the total incidence of adverse reactions in the the two groups [13.33% vs 12.50%](P>0.05).Conclusion On the basis of flunarizine, combined with lamotrigine adjuvant treatment was weel for vestibular migraine, which could effectively improve the expression levels of serum neurotransmitters, alleviate clinical symptoms, and had good safety, it was worth popularizing