水针疗法联合清热祛毒汤治疗寻常型银屑病(血热证)的疗效及其作用机制分析

目的观察分析水针疗法联合清热祛毒汤治疗寻常型银屑病(血热证)的疗效及其作用机制。方法选择2018年8月—2019年7月在我院接收治疗的112例寻常型银屑病患者作为分析对象,采取随机分组的办法将其分为对照组56例和研究组56例,对照组患者采取水针疗法治疗,研究组在对照组的基础上联合清热祛毒汤治疗。比较分析2组患者的疗效;治疗前后的中医证候评分、皮肤病生活质量指数(DLQI)评分;治疗前后皮损面积、浸润、鳞屑、红斑等评分;治疗前后肿瘤坏死因子α(TNF-α)、白细胞介素6(IL-6)、血管内皮生长因子(VEGF)水平变化情况。结果研究组患者治疗总有效率89.29%明显高于对照组73.21%(P<0.05);治疗前,2组患者的中医证候评分、DLQI评分、皮损面积、浸润、鳞屑、红斑等评分及TNF-α、IL-6、VEGF等水平比较(P>0.05);研究组患者治疗后的中医证候评分与DLQI评分明显低于治疗前(P<0.05);研究组患者治疗后的皮损面积、浸润、鳞屑、红斑等评分明显低于对照组(P<0.05);研究组患者治疗后的TNF-α、IL-6、VEGF等水平明显低于对照组(P<0.05)。结论对寻常型银屑病患者采取水针疗法联合清热祛毒汤治疗的疗效显著,能有效改善中医证候表现,提高生活质量,减轻皮损程度,降低炎症反应,其作用机制可能与炎症因子水平、皮损血管增生相关。

Analysis on the Therapeutic Effect and Action Mechanism of Acupoint Injection Combined with Qingre Qudu Decoction in the Treatment of Psoriasis Vulgaris(Blood Heat Syndrome)

Objective To observe and analyze the clinical effect and action mechanism of acupoint injection combined with Qingre Qudu decoction in treatment of psoriasis vulgaris(blood heat syndrome).Methods 112 cases of patients with psoriasis vulgaris and who received in our hospital from August 2018 to July 2019 were selected as the analysis objects,and the patients were randomly divided into the control group(56 cases)and the study group(56 cases)by the random grouping method.The control group was treated with acupoint injection,while the study group was treated with Qingre Qudu decoction on the basis of the control group.The clinical effects,the TCM syndrome score,skin disease quality of life index(DLQI)score,skin lesion area,infiltration,scales,erythema score,etc.Before and after treatment,and the changes of TNF-alpha,IL-6 and vascular endothelial growth factor(VEGF)levels of two groups were compared and analyzed.Results The total effective rate in the study group was 89.29%,which was significantly higher than that in the control group(73.21%)(P<0.05).Before the treatment,the scores of TCM syndromes,DLQI score,lesion area,infiltration,scales,erythema,TNF-a,IL-6,and VEGF were compared between the two groups(P>0.05).The scores of TCM syndromes and DLQI in the study group after treatment were significantly lower than those before treatment(P<0.05).The scores of lesion area,infiltration,scales and erythema in the study group after treatment were significantly lower than those in the control group(P<0.05).The levels of TNF-a,IL-6 and VEGF in the study group after treatment were significantly lower than those in the control group(P<0.05).Conclusion The clinical effect of acupoint injection combined with Qingre Qudu decoction in the treatment of psoriasis vulgaris is significant,which can effectively improve the symptoms of traditional Chinese medicine,improve the quality of life,reduce the degree of skin lesions,and reduce inflammatory response.Its mechanism may be related to the level of inflammatory factors and vascular proliferation in skin lesions.